Background
During pregnancy, urinary infections are an important cause of maternofetal morbidity and mortality and may lead to several complications.
Objective
To verify whether the use of antibiotic therapy in a single dose when compared with multiple doses in lower tract urinary infections during pregnancy is effective to obtain microbiologic cure.
Search strategy
Online databases were searched. Keywords used were "single‐drug dose", "antibiotic", "fosfomycin", "amoxicillin", "trimethoprim", "pregnancy", and "urinary tract infection".
Selection criteria
Studies were included if they were randomized controlled trials, the population was pregnant woman, microbiologic cure was attained, and one of the treatment groups received single‐dose antibiotic therapy.
Data collection and analysis
Preselected studies have been independently read by pairs, and data were extracted according to a predetermined sheet. The Cochrane tool was used for the risk of bias.
Main results
A total of 1063 women from nine studies were included. The primary outcome was the microbiologic cure attested by urine culture. When compared with the multiple‐day use of antibiotics, the single‐dose treatment has shown statistically similar results in reaching culture cure (odds ratio 1.02, 95% confidence interval 0.73–1.44).
Conclusion
The current study has shown that the use of single‐dose treatment for lower tract urinary infections during pregnancy can be recommended, especially using fosfomycin.
Systematic review registration
This review has not been registered.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.