Breast cancer is the most frequent cancer in women worldwide. Screening programs and imaging improvements have increased the detection of clinically occult nonpalpable lesions requiring preoperative localization. Imageguided wire localization (WGL) is the current standard of care for the excision of non-palpable carcinomas during breast conserving surgery (BCS). Due to the current limitations of intraoperative tumor localization approaches, the integration of the information from multimodal imaging may be especially relevant in surgical planning. This work presents a workflow to perform a prone image-to-surgical physical data alignment in order to determine the correspondence between the tumor identified in the preoperative image and the final position of the tumor in the surgical position. The evaluation of the methodology has been carried out in 18 cases achieving an average localization error of 10.40 mm and 9.84 mm in 11 small lesion cases (less than 1 cm in diameter).
Breast cancer is the most common cancer in women worldwide. Screening programs and imaging improvements have increased the detection of clinically occult non-palpable lesions requiring preoperative localization. Wire guided localization (WGL) is the current standard of care for the excision of non-palpable carcinomas during breast conserving surgery. Due to the current limitations of intraoperative tumor localization approaches, the integration of multimodal imaging information may be especially relevant in surgical planning. This research proposes a novel method for performing preoperative imageto-surgical surface data alignment to determine the position of the tumor at the time of surgery and aid preoperative planning. First, the volume of the breast in the surgical position is reconstructed, and a set of surface correspondences is defined. Then, the preoperative (prone) and intraoperative (supine) volumes are co-registered using landmark driven non-rigid registration methods. We compared the performances of diffeomorphic and Bspline based registration methods. Finally, our method was validated using clinical data from 67 patients considering as target registration error (TRE) the distance between the estimated tumor position and the reference surgical position. The proposed method achieved a TRE of 16.21 ± 8.18 mm and it could potentially assist the surgery planning and guidance of breast cancer treatment in the clinical practice.
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