A Cobalt-catayzed oxidative isocyanide insertion of aminoquinoline benzamides has been developed. The reaction proceeded smoothly by using Ag 2 CO 3 as the oxidant in PhCl at 120 o C and delivered products in moderate to excellent yields with excellent functional group tolerance. The transformation is supposed to undergo the ortho C-H activation and isocyanide insertion of C-Co species toward the benzamides. Attractive features of this system include the use of low cost cobalt catalyst, the easyhandling operation, and readily available substrates.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.