Highly para-selective palladium-catalyzed direct arylation of phenols with aryl iodides was demonstrated by taking advantage of the formal inverse direct arylation strategy. A series of 4-aryl phenols were synthesised by employing water as a "green" solvent under mild reaction conditions.
Palladium‐catalyzed dehydrogenative coupling reactions between acetanilides and benzylic alcohols under aqueous conditions are reported. A wide range of benzophenone derivatives could be obtained in good to excellent yields up to 98 %. Mechanism studies showed that a bimetallic palladium cyclopalladated complex might be involved in the catalysis.
A palladium(II)‐catalyzed direct arylation of methylene C(sp3)H bonds by 2‐methyl‐7‐aminobenzoxazole as an effective auxiliary is reported. This process exhibited high beta‐site selectivity, broad substrate scope, and compatibility with different functional groups with moderate to high yields up to 89%.magnified image
An efficient cobalt-catalyzed
C–H acetoxylation of phenols
has been developed by using PIDA (phenyliodine diacetate) as a sole
acetoxy source to synthesize pyrocatechol derivatives for the first
time. The key feature of this method is the use of earth-abundant
metal cobalt as the green and inexpensive catalyst for the acetoxylation
of C(sp2)–H bonds under neutral reaction conditions.
Furthermore, the gram-scale reaction and late-stage functionalization
demonstrated the usefulness of this method.
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