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Background Chemotherapy induced diarrhea (CID) is a common side effect in patients receiving chemotherapy for cancer. The aim of our study was to explore the association between gut microorganisms and CID from the CapeOX regimen in resected stage III colorectal cancer (CRC) patients. Results After screening and identification, 17 stool samples were collected from resected stage III CRC patients undergoing the CapeOX regimen. Bacterial 16S ribosomal RNA genes was sequenced, and a bioinformatics analysis was executed to screen for the distinctive gut microbiome and the functional metabolism associated with CID due to the CapeOX regimen. The gut microbial community richness and community diversity were lower in CID (p < 0.05 vs control group). Klebsiella pneumoniae was the most predominant species (31.22%) among the gut microbiome in CRC patients with CID. There were 75 microorganisms with statistically significant differences at the species level between the CRC patients with and without CID (LDA, linear discriminant analysis score > 2), and there were 23 pathways that the differential microorganisms might be involved in. Conclusions The gut microbial community structure and diversity have changed in CRC patients with CID. It may provide novel insights into the prevention and treatment of CID. Electronic supplementary material The online version of this article (10.1186/s13099-019-0299-4) contains supplementary material, which is available to authorized users.

The microstructural evolution and densification kinetics of a-alumina were investigated and compared between conventional sintering and microwave sintering at 2.45 GHz in the intermediate stage, where the microwave seems to be the most efficient. Based on classical kinetics models, the calculated kinetics parameter demonstrated that the densification is greatly influenced by the presence of an electromagnetic field during sintering. It was assumed that the grain boundary diffusion is enhanced by an electromagnetic pressure induced by the microwave.

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International audienceThe effects of MgO doping and specific surface area of powder on microwave sintering behavior of -Al2O3 were investigated. A comparative study was simultaneously achieved in conventional and microwave heating with an identical thermal process. The experimental results show that both MgO and particle size have significant influence on microwave enhancement in the densification of the alumina samples. It is found that an amount of MgO surrounding the solubility limit in Al2O3 or leading to second phase precipitation of MgAl2O4 spinel induces more significant microwave enhancement. A significant microwave gain in densification is also observed while powder has a high specific surface area. These results indicate that the enhancements during microwave sintering processes are associated with the formation of lattice defect and with the increase in concentration of grain-boundary region