Tailoring the mechanical property and cell-biological response of β-tricalcium phosphate composite bioceramics by SrO-P2O5-Na2O based additive

Modification of honeycomb bioceramic scaffolds for bone regeneration under the condition of excessive bone resorption

“…It is known that that PG has significantly higher solubility compared with calcium phosphates. Previous studies demonstrated that after sintering β‐TCP with 20 wt % PG additive, the PG residues were present in the bioceramics; substantial ions of Ca and P were rapidly released from the composite bioceramics during immersion in the solution . Therefore, the TCP‐GPGs extracts showed remarkably higher Ca concentration than TCP extract, as well as notably higher P concentration compared with H‐DMEM and TCP extract.…”

“…The β‐TCP powders (d 50 = 3.0 μm) and GPGs powders (d 50 = 5.4 μm) were obtained by solid‐phase reaction and melt‐quenching method, respectively, in accordance to the protocols described in previous work . P 2 O 5 , CaCO 3 , Na 2 CO 3 , and Ga 2 O 3 were used as starting materials for synthesizing GPGs.…”

“…The commercial drug strontium ranelate, which is based on strontium, is currently well accepted for treating osteoporosis in the postmenopausal women . Plentiful researches have demonstrated that incorporation of strontium into biomaterials promoted osteogenic differentiation and inhibited osteoclastic activity in vitro and in vivo …”

“…Great efforts have been made to increase the mechanical strength of β‐TCP bioceramics . Introduction of phosphate‐based glass (PG) additive is an efficient approach to improve the mechanical strength of β‐TCP bioceramics, because PG additive enables more effective liquid‐state sintering for β‐TCP . In general, the bioceramics are processed to porous form to conduct the bone growth.…”

“…13 Plentiful researches have demonstrated that incorporation of strontium into biomaterials promoted osteogenic differentiation and inhibited osteoclastic activity in vitro and in vivo. [14][15][16][17][18] Gallium (Ga) is another potent element to decrease bone resorption by inhibiting proliferation, differentiation and resorption activity of osteoclast. 19,20 Substantial clinical trials and animal experiments have demonstrated the positive effect of systemic administration of Ga ions on treating the bonerelated diseases (osteoporosis, osteopenia, Paget's disease, multiple myeloma, etc.)…”