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Background: QTc prolongation is one of the possible complications in patients with schizophrenia taking antipsychotics, which leads to malignant cardiac arrhythmia. No meta-analysis has been reported assessing the prevalence and correlated risk factors for QTc prolongation. Methods: This meta-analysis aimed to assess the evidence for the prevalence of QTc prolongation and correlated risk factors in patients with schizophrenia taking antipsychotics. Web of Science and PubMed were searched according to preset strategy. The quality of research was assessed by the Newcastle–Ottawa Scale (NOS). Results: In all, 15 studies covering 15,540 patients with schizophrenia taking antipsychotics were included. Meta-analysis showed that the prevalence of QTc prolongation in patients with schizophrenia taking antipsychotics was about 4.0% (95% confidence interval (CI): 3.0%–5.0%, p < 0.001). The prevalence was about 4.0% in Asia (95%CI: 3.0%–6.0%, p < 0.001), about 5.0% in Europe (95%CI: 2.0%–7.0%, p < 0.001), and about 2.0% in America (95%CI: 1.0%–3.0%, p < 0.001). Sensitivity analyses indicated the robustness of the result. Publication bias analysis reported a certain publication bias ( t = 3.37, p = 0.012). Meta-regression suggested that female and elderly patients were clinically associated with a higher prevalence of QTc prolongation. According to included studies, smoking, comorbidity of cardiovascular disease, and abnormal levels of high-density lipoprotein/low-density lipoprotein might be related to QTc prolongation in patients with schizophrenia taking antipsychotics. Conclusions: The prevalence of QTc prolongation in patients with schizophrenia taking antipsychotics was about 4.0%. Female and elderly patients were more likely to experience QTc prolongation. Close electrocardiogram monitoring was suggested in these at-risk populations.

Aims and ObjectivesTo determine the global prevalence of nursing burnout syndrome and time trends for the last 10 years.BackgroundThe prevalence of burnout syndrome varied greatly in different regions in the last 10 years, so the average prevalence and time trends of nursing burnout syndrome for the last 10 years were not completely clear.DesignA meta‐analysis conducted in the PRISMA guidelines.MethodsCINAHL, Web of Science, and PubMed were searched for trials on the prevalence of nursing burnout syndrome from 2012 to 2022 systematically. Hoy's quality assessment tool was used to evaluate the risk of bias. The global prevalence of nursing burnout syndrome was estimated, and subgroup analysis was used to explore what caused heterogeneity. Time trends for the last 10 years were evaluated by meta‐regression using Stata 11.0.ResultsNinety‐four studies reporting the prevalence of nursing burnout were included. The global prevalence of nursing burnout was 30.0% [95% CI: 26.0%–34.0%]. Subgroup analysis indicated that the specialty (p < .001) and the region (p < .001) and the year (p < .001) were sources of the high heterogeneity. Meta‐regression indicated that it tended to increase gradually for the last 10 years (t = 3.71, p = .006). The trends increased in Europe (t = 4.23, p = .006), Africa (t = 3.75, p = .006) and obstetrics (t = 3.66, p = .015). However, no statistical significance was found in ICU (t = −.14, p = .893), oncology (t = −0.44, p = .691) and emergency department (t = −0.30, p = .783).ConclusionsA significant number of nurses were found to have moderate‐high levels of burnout syndrome for the last 10 years. The meta‐analysis also indicated an increased trend over time. Therefore, more attention to the prevalence of nursing burnout syndrome is urgently required.Relevance to Clinical PracticeHigh prevalence of nursing burnout may attract more attention from the public. This analysis may serve as an impetus for relevant policy to change nurses' working conditions and reduce the occurrence of burnout.

Background: Loneliness is a common public health problem that influences people’s physical and mental health. There is a high incidence of loneliness in adolescents. Some research suggested that smartphone or Internet addiction (SA or IA) may be a factor. But the relationship between loneliness and SA or IA is not completely clear among adolescents. We aim to estimate the correlation coefficient r between them. Methods: Databases, consisting of PubMed and Web of Science, were retrieved systematically for studies of the association between adolescents’ loneliness and SA or IA. The Newcastle-Ottawa Scale was chosen as an assessment tool in this analysis. We estimated the correlation coefficient r between loneliness and SA or IA and drew a forest plot. Moreover, moderator analyses were also conducted to explore what leads to heterogeneity in our study. Results: 21 studies were finally included in our analysis with 27,843 samples. The pooled correlation coefficient r was 0.252 (95% confidence interval: [0.173, 0.329]; p < 0.001) with low heterogeneity (I2 = 0.000%; Q = 23.616; p < 0.001), indicating a moderate positive association. The funnel plot indicated small publication bias. A one-study removal sensitivity analysis indicated there was no significant difference between these studies. Meta-regression indicated no significant difference between the results and age (Q = 11.94, df = 18, p = 0.8504). Conclusions: Our analysis indicated a moderate positive association between loneliness and SA or IA. The results may attract the attention of some experts who study adolescent psychological problems and behavioral problems and may provide ideas for their research in the future.

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BackgroundDuring the COVID‐19 epidemic, palliative care has become even more indispensable for cancer patients.AimTo identify the changes in palliative care for cancer patients and improvements in palliative care quality during the COVID‐19 pandemic.DesignA systematic review and narrative synthesis was conducted in PubMed, Embase and Web of Science. An evaluation tool using mixed methods was used to assess the quality of the study. The main relevant themes identified were used to group qualitative and quantitative findings.ResultsA total of 36 studies were identified, primarily from different countries, with a total of 14,427 patients, 238 caregivers and 354 health care providers. Cancer palliative care has been experiencing several difficulties following the COVID‐19 pandemic, including increased mortality and infection rates as well as delays in patient treatment that have resulted in poorer prognoses. Treatment providers are seeking solutions such as electronic management of patients and integration of resources to care for the mental health of patients and staff. Telemedicine plays an important role in many ways but cannot completely replace traditional treatment. Clinicians strive to meet patients' palliative care needs during special times and improve their quality of life.ConclusionsPalliative care faces unique challenges during the COVID‐19 epidemic. With adequate support to alleviate care‐related challenges, patients in the home versus hospital setting will be able to receive better palliative care. In addition, this review highlights the importance of multiparty collaboration to achieve personal and societal benefits of palliative care.Patient or Public ContributionNo Patient or Public Contribution.

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