Thyroid hormones exert a wide range of functions in several organs, including cardiovascular system, 1,2 lipid metabolism, 3-5 muscular function, 6 erythropoiesis, 7 and oxidative stress. 8 They also exert various effects on nervous system. Overt thyroid disorders are associated with several forms of cognitive impairment, depression, anxiety disorders, and peripheral neuropathies. 9,10 Cognition consists of several and specific neuronal systems which include attention, perception, memory, language, psychomotor, and executive functions. All these aspects, together with mood decrements, may be deeply affected by thyroid disease. Overt hypothyroidism has been linked with negative effects to various aspects of cognition. Cognitive deficits have also been reported in overt hyperthyroidism, being poorer performance on tests of attention, memory, or mental alertness the cognitive deficits most frequently observed. 11,12 Thyroid function changes with age, and since cogni-DELITALA ET AL. AUTH O R ' S CO NTR I B UTI O N Alessandro P Delitala helped in article designing and drafting; Marta Manzocco and Federico G Sinibaldi provided support in data collection and article drafting; and Giuseppe Fanciulli did critical revision of the article. O RCI D Alessandro P. Delitala