Andrographispaniculata (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from A. paniculata, such as andrographolide and its analogs, have attracted much interest for their potential treatment against several virus infections, including SARS-CoV-2. The mechanisms of action in inhibiting viral infections can be categorized into several types, including regulating the viral entry stage, gene replication, and the formation of mature functional proteins. The efficacy of andrographolide as an antiviral candidate was further investigated since the phytoconstituents of A. paniculata exhibit various physicochemical characteristics, including low solubility and low bioavailability. A discussion on the delivery systems of these active compounds could accelerate their development for commercial applications as antiviral drugs. This study critically reviewed the current antiviral development based on andrographolide and its derivative compounds, especially on their mechanism of action as antiviral drugs and drug delivery systems.
Sea cucumber is an important food and remedies in Eastern hemisphere. However, less study have been performed to identify health benefit effects of sea cucumber from tropical region. In this study, radical scavenging activity of sea cucumber from Mataram - Lombok [Holothuria leucospilota, Holothuria atra, Holothuria fuscocinerea, and Holothuria excellens] were studied. Compared to other species at concentration of 0.1 mg mL–1, H. atra extract showed strongest scavenging activity in 2,2-Diphenyl-1-picrylhydrazyl (DPPH) (13.14 ± 2.17) % and absorbance value of β-carotene linoleic acid model at 180 min was (3.32 ± 1,12). H. atra extract were further fractionated, and ethyl acetate fractions (fr. 6) significantly inhibit radical activity at 180 min with the absorbance value of 2.84 ± 0.2. It can be concluded that H. atra is an important sea cucumber from tropical region.
The Influence of nutrient and temperature to the antibacterial selectivity of Sponge AssociatedBacteria M1, M2 and M3 respectively in range were 81,8-90,9%; 50-87,5% and; 66,7 -100%. This results showed that less nutrient of media will rise the number of antibacterial activity strains,and decreasing of bacterial density. This study reported that the minimum nutrient of isolation media and heat shock treatment could be used for selecting the antibacterial strains of sponge associated bacteria.
Sea cucumber is marine commodity widely distributed throughout Indonesian waters, Indonesia exported sea cucumber to Hongkong, Japan, Korea, Singapore, Taiwan, Malaysia and Australia. This study aims to characterize sea cucumber, determine the antioxidant, and antibacterial activity of cultivated sea cucumbers. Sea cucumbers are cultivated in the pond for 12 months, with the weight and size average 160.9 grams, and 15.3 cm at harvest. The sea cucumbers were characterized by measuring their proximate and heavy metals content. The samples were extracted using water at 60°C, 70°C, 80°C, and soxhletation with 70% ethanol. Furthermore, the antibacterial analysis was tested on three bacteria, namely Staphylococcus aureus, Bacillus subtilis, and Escherichia coli and antioxidants were analyzed using the ABTS method. The results showed that the sea cucumber protein content was 78.77%, fat content was 1.66%, and carbohydrate was 3.80%. Heavy metal content of cultivated sea cucumbers, including as 1.12 mg/kg, Pb 0.15 mg/kg, Ni, Hg, and Cd were not detected. Antibacterial test results showed all the extract of sea cucumber could not inhibit the growth of bacteria. The best antioxidant activity was found in dried sea cucumbers extracted using the soxhletation method with IC50 value 62.72 μg/mL.
Mangroves are still considered as underexploited marine resources in Indonesia, and functional materials from Indonesian mangroves are not characterized yet. In this study, different part of mangroves (Sonneratia alba leaves - SAL, Sonneratia alba roots - SAR, Sonneratia alba fruit - SAF, Rhizhopora mucronata - RMF, Rhizhopora lamarckii - RLF) were hydrolyzed using the subcritical water extraction (SCWE) system at 120 ºC. Mangroves hydrolysates (SAL, SAR, SAF, RMF and RLF) were further analyzed for total protein, sugar, reducing sugar, saponin and flavonoid content. The antioxidant capacity and functional material contents including total sugar, reducing sugar, protein, flavonoid and saponin contents. The highest flavonoid and saponin contents were obtained from RLF with the value of 20.13±0.17 mg/g and 31.83±0.18 mg/g, respectively. The antioxidant capacity and antibacterial properties of mangroves hydrolysates varied significantly based on the sample materials, with RLF showing the highest total antioxidant activity and antibacterial activity. The results of our study suggest that tropical mangroves especially R. lamarckii could be valorized efficiently, as a source of bioactive material using subcritical water extraction
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