Aim: Drug-eluting beads are usually applied for the treatment of advanced hepatocellular carcinoma. Oxaliplatin was suggested as first-line therapy for advanced non–small-cell lung cancer. However, there has been little investigation about the application of drug-eluting beads transarterial chemoembolization (DEB-TACE) with oxaliplatin-loaded CalliSpheres beads (CB) for the treatment of unresectable or advanced lung cancer. We aimed to investigate the safety and efficacy of oxaliplatin-loaded DEB-TACE for the treatment of unresectable or advanced lung cancer.Methods: From January 2019 to December 2021, all patients with primary unresectable or advanced lung cancer who underwent DEB-TACE with oxaliplatin-loaded CB were retrospectively enrolled. This study defined overall survival and objective response rate (ORR) as the primary endpoints, disease control rate (DCR) and progression-free survival (PFS) as the secondary endpoints.Results: A total of 33 sessions of DEB-TACE were performed in 20 patients, with a mean of 1.7 ± 1.0 sessions. A total of 55 arteries were emoblized by CB, including 40 bronchial arteries, 13 intercostal arteries, one suprarenal artery and one inferior phrenical artery. No procedural-related mortality or severe complications were observed. The median tumor diameter was 49.0 [Interquartile range (IQR) 37.8–66.8] mm before DEB-TACE, and decreased to 38.8 (IQR 27.7–56.9), 26.1 (IQR 19.1–48.8), and 20.5 (IQR 13.1–49.7) mm at 1, 3 and 6 months later (p = 0.04). The ORR and DCR at 1, 3, and 6 months after DEB-TACE were 28.6% and 92.9%, 38.5% and 84.6%, 30.8% and 61.5%, respectively. The median PFS and median overall survival was 9.9 and 29.6 months, respectively.Conclusion: DEB-TACE with oxaliplatin-loaded CB is suggested as a safe, effective and well-tolerated treatment for patients with unresectable or advanced lung cancer.
Considering the influence of the fixing method of the component in the system on its results in ultrasonic infrared thermography testing, the detection experiments of the cracked plat structure with fixing at one end and fixing at two ends are carried out through different fixing methods of the equivalent structure. The results show that for the same structure to be detected, the more the bounds are fixed, the more the degrees of freedom are restricted, the less ultrasonic energy is dissipated during the inspection process, and the better the inspection effect. The work has positive significance for the selection of detection parameters in ultrasonic infrared thermography testing, helpful to provide some references for it.
The accurate description of acoustic emission signals produced by the localized fault of a rolling element bearing plays an important role in its feature extraction and analysis. This paper analyzes the excitation mechanisms and develops the analytical model of acoustic emission signals produced when the rolling element bearing passes across the localized fault on the inner or outer race. Based on the analytical model, the spectral characteristics are discussed substantially. Simulations and experiments are carried out to validate the efficacy of the model developed in the paper. The experimental results show that the response signal thus produced has two parts. The first one is produced by the entry of the rolling element bearing, while the other is produced by the departure of the rolling element bearing. The energy of both parts is concentrated around the resonance frequency of the acoustic emission transducer. Generally, the interval of adjacent acoustic emission events is not equivalent to each other and the corresponding spectrum is continuous in the high frequency band.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.