Intramolecular Ritter reactions of 2-(2-cyanoethyl)tetrahydrocyclopenta [b]indole and -carbazole derivatives, prepared by a sequence of two different α-substitutions and Grignard reactions of the indole-based ketones 4-methyl-1,4-dihydrocyclopenta [b]indol-3(2H)-one and 9-methyl-2,3,4,9-tetra-
Various conformationally constrained forms of the diarylbutylamine pharmacophore were accessed by incorporating it into heterocyclic ring systems, i.e., indeno [1,2-b]
Fused pyridine derivatives R 0450 Intramolecular Ritter Reactions of 2-(2-Cyanoethyl)tetrahydrocyclopenta[b] indole and -carbazole Derivatives. -Intramolecular Ritter reactions are used as key steps in the synthesis of lactam compounds. They are required as precursors of constrained indole analogs of NK-1 and dopamine receptor ligands. -(MAERTENS, F.; VAN DEN BOGAERT, A.; COMPERNOLLE*, F.; HOORNAERT, G. J.; Eur.
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