CONTENTS 1. Introduction 4964 2. How Is the Extent of a Weak Interaction Best Quantified? 4965 3. Metal-Ion Complexes with Phosph(on)ate Groups as Primary Binding Sites 4966 3.1. Extent of the HydroxylÀM 2þ Interaction in Complexes of Hydroxymethylphosphonate 4966 3.2. Metal-IonÀGlycerol 1-Phosphate Systems: A Decreasing Solvent Polarity Favors Hydro-xylÀM 2þ Interactions 4967 3.3. Some Generalizations Regarding Phosph-(on)ate Ligands with a Weakly Coordinating Second Site 4968 4. Metal-Ion Complexes with Carboxylate Groups as Primary Binding Sites 4969 4.1. Extent of Chelate Formation in Complexes of Hydroxyacetate and Related Ligands at I = 0.1 M 4969 4.1.1. Construction of the Reference Lines for Several M 2þ ÀCarboxylate Systems 4969 4.1.2. Extent of Chelate Formation in Metal-Ion Complexes Formed with Hydroxy Carboxylates and Related Ligands 4970 4.2. Extent of Chelate Formation in Complexes of Hydroxyacetate-Type Ligands at I =2M 4972 4.3. Effect of Chelate-Ring Enlargement on the Hy-droxylÀMetal-Ion Interaction 4974 4.4. Decreasing Solvent Polarity Favors the Hydro-xylÀMetal-Ion Interaction in Complexes of Hydroxyacetate and Related O Ligands But Inhibits Thioether Interactions 4975 5. Metal-Ion Complexes with Amino Groups as Primary Binding Sites 4976 5.1. Estimation of Straight-Line Parameters for Complexes Formed with RCH 2 ÀNH 2 Ligands 4976 5.2. Extent of Hydroxyl GroupÀMetal-Ion Binding in Complexes of 2-Aminoethanol and Related Ligands 4978 5.3. Comparison of the Metal-Ion-Binding Properties of 2-Aminoethanol and Triethanolamine 4980 6. Imidazole Residue as a Primary Binding Site in Ligands Containing also a Hydroxyl Group 4982 7. Pyridyl Nitrogen Is an Ideal Primary Metal-Ion-Binding Site for a HydroxylÀMetal-Ion Interaction 4983 8. Isomeric Quantification of Metal-Ion Binding with Ligands Offering Two Hydroxyl Groups 4985 9. Effect of the Primary Binding Site on the Extent of the HydroxylÀMetal-Ion Interaction 4986 10. Extent of HydroxylÀMetal-Ion Interactions in Complexes Having a Bidentate Primary Binding Site 4988 11. Metal-Ion Complexes of Ligands with Two or More Hydroxyl Groups and at Least Four Binding Sites 4991 11.1. Complexes of the Alkaline Earth Ions with Bistris and Some Related Buffers: Reduced Solvent Polarity Favors Metal-IonÀHydroxyl Group Interactions 4991 11.2. Complexes of Several 3d and Related Metal Ions with Bistris and Derivatives 4994 11.3. Quest for Selectivity in Metal-Ion Coordination Involving Hydroxyl Groups 4996 12. General Conclusions 4998 Author Information 4999 Biographies 4999 Acknowledgment 5000 Abbreviations and Definitions 5000 References 5001
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