Context: Type 2 diabetes mellitus (T2DM) patients tend to have lipid abnormalities, thus elevating the risk of complications and mortality. Early detection using a genomic approach could help identify the abnormality of lipid profiles so that it could reduce those burdens. A previous study found a high frequency of mutants in the rs2075604 as the intron area in the STK11 gene. Aims: To analyze the effect of rs2075604 related to lipid abnormalities in newly diagnosed T2DM patients. Methods: This present study conducted a cross-sectional study in the ten public healthcare facilities in Sleman, Yogyakarta. The genetic variants were detected using PCR-RFLP methods. A total of 130 patients who had to consume antidiabetic oral for three months participated in this study. Results: This study revealed that the mutant variant dominated in this population at 61.5%. Mutant genotype, mutant allele, and dominant model reduce the risk of low HDL (OR = 0.33, 95% CI = 0.11-0.99; OR = 0.46, 95% CI = 0.24-0.90; OR = 0.33, 95% CI = 0.12-0.96; respectively). The improvement of low HDL risk by the mutant allele was confirmed through an adjusted model (OR = 0.47, 95% CI = 0.23-0.98). The mutant allele only influenced high LDL risk in the non-adjusted model (OR = 2.22, 95% CI = 1.02-4.82), but it did not found in other models. Conclusions: The mutant of rs2075604 has a protective role in low HDL-c risk in Indonesia. However, further study is required to observe the effect on LDL-c.
Indonesia merupakan negara dengan berbagai macam tanaman tradisional yang berpotensi untuk dijadikan sebagai bahan pengobatan. Tanaman telang (Clitoria ternatea L.) merupakan salah satu tanaman yang mulai dikembangkan sebagai pengobatan. Bagian tanaman telang yang sering digunakan adalah daun dan bunga. Daun dan bunga telang mengandung senyawa yang memiliki aktivitas antioksidan, di antaranya fenolik, flavonoid, antosianin, dan tanin. Aktivitas antioksidan dapat diuji secara in vitro dengan beberapa metode seperti DPPH, ORAC, dan FRAP. Berdasarkan hasil tinjauan pustaka diketahui bahwa daun dan bunga telang memiliki aktivitas antioksidan dan tidak menunjukkan adanya potensi toksik sehingga relatif aman untuk digunakan.
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