Although atrial fibrillation (AF) is the most common sustained atrial arrhythmia, treatment success for this condition remains suboptimal. Information from magnetic resonance imaging (MRI) has the potential to improve treatment efficacy, but there are currently few automatic tools for the segmentation of the atria in MR images. In the study, we propose a LA-Net, a multi-task network optimised to simultaneously generate left atrial segmentation and edge masks from MRI. LA-Net includes cross attention modules (CAMs) and enhanced decoder modules (EDMs) to purposefully select the most meaningful edge information for segmentation and smoothly incorporate it into segmentation masks at multiple-scales. We evaluate the performance of LA-Net on two MR sequences: late gadolinium enhanced (LGE) atrial MRI and atrial short axis balanced steady state free precession (bSSFP) MRI. LA-Net gives Hausdorff distances of 12.43 mm and Dice scores of 0.92 on the LGE (STACOM 2018) dataset and Hausdorff distances of 17.41 mm and Dice scores of 0.90 on the bSSFP (inhouse) dataset without any post-processing, surpassing previously proposed segmentation networks, including U-Net and SEGANet. Our method allows automatic extraction of information about the LA from MR images, which can

Demographic studies suggest that changes in the retinal vasculature geometry, especially in vessel width, are associated with the incidence or progression of eyerelated or systemic diseases. To date, the main information source for width estimation from fundus images has been the intensity profile between vessel edges. However, there are many factors affecting the intensity profile: pathologies, the central light reflex and local illumination levels, to name a few. In this study, we introduce three information sources for width estimation. These are the probability profiles of vessel interior, centreline and edge locations generated by a deep network. The probability profiles provide direct access to vessel geometry and are used in the likelihood calculation for a Bayesian method, particle filtering. We also introduce a geometric model which can handle non-ideal conditions of the probability profiles. Our experiments conducted on the REVIEW dataset yielded consistent estimates of vessel width, even in cases when one of the vessel edges is difficult to identify. Moreover, our results suggest that the method is better than human observers at locating edges of low contrast vessels.

Junctions in the retinal vasculature are key points to be able to extract its topology, but they vary in appearance, depending on vessel density, width and branching/crossing angles. The complexity of junction patterns is usually accompanied by a scarcity of labels, which discourages the usage of very deep networks for their detection. We propose a multitask network, generating labels for vessel interior, centerline, edges and junction patterns, to provide additional information to facilitate junction detection. After the initial detection of potential junctions in junctionselective probability maps, candidate locations are re-examined in centerline probability maps to verify if they connect at least 3 branches. The experiments on the DRIVE and IOSTAR showed that our method outperformed a recent study in which a popular deep network was trained as a classifier to find junctions. Moreover, the proposed approach is applicable to unseen datasets with the same degree of success, after training it only once.

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