In this study, hydrophilic based bioactive nanofibers were produced via an electrospinning and electrospraying simultaneous process. Poly(vinyl alcohol) (PVA), poly(vinyl alcohol)-gelatin (PVA-Gel), and poly(vinyl alcohol)-alginate (PVA-Alg) polymers were used as the matrix material and folic acid (FA) particles were dispersed simultaneously on the surface of the nanofibers. The morphology of the nanofibers (NFs) was uniform and confirmed by scanning electron microscopy. Thermal behavior, chemical structure of the composite nanofibers were investigated by thermogravimetric analysis, and Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy which showed that no chemical bonding between vitamin and polymers. A fast release of FA-loaded electrospun fibers was carried out by UV-Vis in vitro study within the 8 hour-period in artificial sweat solutions (pH 5.44). The obtained PVA/FA, PVA-Gel/FA, and PVA-Alg/FA fibers released 49.6%, 69.55%, and 50.88% of the sprayed FA in 8 h, indicating the influence of polymer matrix and polymer-drug interactions, on its release from the polymer matrix. Moreover, biocompatibility of all developed novel NFs was assessed by two different cytotoxicity tests, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and neutral red uptake (NRU) assay in L929 (mouse fibroblasts) cell lines. In all cases, it is concluded that these new electrospun fibers had fast-release of the vitamin and the hybrid process is suitable for transdermal patch applications, especially for skin-care products. The results of cytocompatibility assays on L929 reveal that all prepared NFs have no or slight cell toxicity. PVA and PVA-Gel with/without FA nanofibers seems more biocompatible than PVA-Alg nanofibers.
Macroporous polymer composites with photocatalytic activity are prepared by the polymerization of surface modified TiO2 nanoparticle stabilized high internal phase emulsions. Poly(ethylene glycol‐b‐propylene glycol‐b‐ethylene glycol) triblock copolymer is used to synthesize surface modified TiO2 anatase via a sol–gel method. Macroporous composites are obtained by the ring opening metathesis polymerization of dicyclopentadiene within the particle‐stabilized high internal phase emulsion templates. Photocatalytic activity of the resulting macroporous polymer composites is described by the kinetic data of the heterogeneous photocatalytic degradation reaction of 4‐nitrophenol.
In this study, bioactive fibers were produced using polyvinyl alcohol (PVA), gelatin, polyvinyl pyrolidone (PVP) as a polymer matrix and different amounts of folic acid (FA) as an vitamin by using electrospinning method. Loading of the folic acid in the polymers was determined by the Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), morphologies and average diameters were analyzed by Scanning Electron Microscopy (SEM) and Thermal Gravimetric Analysis (TGA) was applied for determining thermal behaviors.The FTIR spectra TGA showed the successful incorporation of folic acid to the fibers. SEM images showed that various smooth and heterogenous electrospun fibers were produced with average diameters ranging from 125 nm to 980 nm. In vitro study was carried out by using FA dissolved in artificial sweat solution (acidic media, pH 5.44) and UV-Vis analysis of electrospun fibers were evaluated. In vitro release studies showed the FA loaded nanofibers had initial vitamin burst release behavior. The maximum vitamin release percentage of PVA/FA, gelatin/FA and PVP/FA fibers was obtained 86.88 %, 80.2 % and 76.66 %, respectively. From these results, the FA-loaded fibers are potential candidates for transdermal patches and topical applications.
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