Co-electrospun-electrosprayed PVA/folic acid nanofibers for transdermal drug delivery: Preparation, characterization, and in vitro cytocompatibility

Parın, Fatma Nur; Aydemir, Çiğdem İnci; Taner, Gökçe; Yıldırım, Kenan

doi:10.1177/1528083721997185

Cited by 28 publications

(34 citation statements)

References 81 publications

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“…Polymer solutions were prepared as in the previous study [ 10 ]. PVA granules were dissolved in distilled water at 90 °C until a 10% ( w / w ) homogenous PVA solution was produced.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, the increased hydrophilicity supplied by natural polymers is favorable when carrying hydrophilic drugs. Nanofibrous scaffolds made of natural and synthetic polymers were shown to be suitable for designing drug release systems via the electrospinning of blended polymers or combination with bioactive agents [ 9 , 10 , 11 , 12 , 13 , 14 ]. Previously, electrospun nanofibers have been produced from single polymer sources, and more recently, polymer combinations have been created to develop so-called polyblend nanofibers.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

et al. 2021

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The fabrication of skin-care products with therapeutic properties has been significant for human health trends. In this study, we developed efficient hydrophilic composite nanofibers (NFs) loaded with the folic acid (FA) by electrospinning and electrospraying processes for tissue engineering or wound healing cosmetic applications. The morphological, chemical and thermal characteristics, in vitro release properties, and cytocompatibility of the resulting composite fibers with the same amount of folic acid were analyzed. The SEM micrographs indicate that the obtained nanofibers were in the nanometer range, with an average fiber diameter of 75–270 nm and a good porosity ratio (34–55%). The TGA curves show that FA inhibits the degradation of the polymer and acts as an antioxidant at high temperatures. More physical interaction between FA and matrices has been shown to occur in the electrospray process than in the electrospinning process. A UV-Vis in vitro study of FA-loaded electrospun fibers for 8 h in artificial acidic (pH 5.44) and alkaline (pH 8.04) sweat solutions exhibited a rapid release of FA-loaded electrospun fibers, showing the effect of polymer matrix–FA interactions and fabrication processes on their release from the nanofibers. PVA-CHi/FA webs have the highest release value, with 95.2% in alkaline media. In acidic media, the highest release (92%) occurred on the PVA-Gel–CHi/sFA sample, and this followed first-order and Korsmeyer–Peppas kinetic models. Further, the L929 cytocompatibility assay results pointed out that all NFs (with/without FA) generated had no cell toxicity; on the contrary, the FA in the fibers facilitates cell growth. Therefore, the nanofibers are a potential candidate material in skin-care and tissue engineering applications.

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“…Polymer solutions were prepared as in the previous study [ 10 ]. PVA granules were dissolved in distilled water at 90 °C until a 10% ( w / w ) homogenous PVA solution was produced.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

et al. 2021

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“… Glycerol is useful in obtaining homogenous and non-brittle membranes. Regarding alginate-based, alginate and PVP based, and alginate and PVA based membranes, these can be utilized to enable the release of each active substance in membranes with a single active substance [ 37 ]. For membranes that enable the release of both active substances, based on the obtained results, we can only recommend the homogenous and non-brittle alginate, PVA and glycerol-based membrane with both active substances visible.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding alginate-based, alginate and PVP based, and alginate and PVA based membranes, these can be utilized to enable the release of each active substance in membranes with a single active substance [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Preliminary Study for the Preparation of Transmucosal or Transdermal Patches with Acyclovir and Lidocaine

et al. 2021

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The present study aimed to prepare and evaluate patches for the controlled release of lidocaine/acyclovir and the binary mixture between lidocaine: acyclovir in the oral cavity. Mucoside adhesive patches containing 12.5 mg/cm2 lidocaine/acyclovir or binary mixture base were developed by a solvent casting method using sodium alginate, polyvinylpyrrolidone (PVP), glycerol (Gly), polyvinyl alcohol (PVA), and Span 80 (S). Binary mixtures between all components were prepared before the patches’ formulation in order to be able to check the substance compatibility. All formulated patches were analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). FT-IR and TGA analyses were also used to check compatibility between binary mixtures. The study establishes which membranes are indicated in the controlled release of lidocaine/acyclovir and those membranes that contain both active principles. Membranes based on alginate, PVP, and PVA can be used to release the active substance. Simultaneously, membranes with SPAN used as a gelling agent were excluded due to the interaction with the active substance. The following membranes composition have been chosen for lidocaine release: Alginate:Gly and Alginate:Gly:PVP. At the same time, the following membrane compositions were chosen for acyclovir membranes: Alginate:Gly:PVP and Alginate:PVA:Gly. Both active substances could be included to obtain a homogeneous distribution only in the membrane based on alginate, PVA, and Gly.

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“…One approach to combating skin aging is to apply herbal phenolics and antioxidants to the skin. Folic acid (FA) is a significant antioxidant-rich B-complex vitamin that aids in the formation of healthy skin cells [62]. The utilization of folic acid as a beauty patch has been investigated by spraying it onto nanofiber surfaces.…”

Section: Nanofibersmentioning

confidence: 99%

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

Parın¹

2022

B-Complex Vitamins - Sources, Intakes and Novel Applications

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Vitamins are regarded as vital nutrients because, when combined, they performed hundreds of functions in the body. They strengthen bones, heal wounds, and boost your immune system. In addition, they transform food into energy and heal cellular damage. In this regard, B-complex vitamins, such as thiamine, riboflavin, and niacin are soluble vitamins that serve as coenzymes in energy metabolism enzymatic activities which building blocks of a healthy body. However, B-complex vitamins are sensitive to light, pH conditions, and temperature. Consequently, they must be encapsulated before they may be used in pharmaceuticals. Recently, it is mainly focused on reducing drug degradation or loss, increase drug bioavailability, limit adverse effects, and improve drug accumulation in the targeted location. To maintain optimum bioavailability during a defined term of therapy, the fraction of drug dosage released from a controlled release product must be significant enough to adjust for the quantity of active drug metabolized and/or eliminated from the body over the same period. Drug release systems also aim to increase the effectiveness of the drug and treat the damaged area. In this chapter, it is aimed to study the production of the vitamin-loaded polymer systems in various forms, such as micro/nanoparticles, micelle, hydrogel, liposome, and nanofiber, as well as release studies in pharmaceutical and biomedical applications.

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Co-electrospun-electrosprayed PVA/folic acid nanofibers for transdermal drug delivery: Preparation, characterization, and in vitro cytocompatibility

Cited by 28 publications

References 81 publications

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

Fabrication and Characterization of Electrospun Folic Acid/Hybrid Fibers: In Vitro Controlled Release Study and Cytocompatibility Assays

Preliminary Study for the Preparation of Transmucosal or Transdermal Patches with Acyclovir and Lidocaine

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

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