The main degradation pathways of apixaban, a novel anticoagulant drug acting as factor Xa inhibitor, has been established based on the degradation products identification using liquid chromatography coupled to multistage high resolution mass spectrometry.
The major degradation mechanisms of dabigatran etexilate were deduced in the context of stress testing. Under hydrolytic stress conditions, O-dealkylation may occur along with formation of benzimidic acid derivatives.
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Tirofiban in aqueous solution mostly photodegrades through photosensitized oxidation reactions and the photoproducts formed are not structurally alerting for genotoxicity.
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