3b.

BackgroundModafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy and other excessive sleepiness. Whereas favorable effects of modafinil on cognitive functions have been shown in a large number of studies, there are very few reports presenting the effects of modafinil electrophysiologically. The aim of this study was to investigate the effects of modafinil on auditory P300 latency and amplitude electrophysiologically.Material/MethodsEighteen patients (age range: 16–48 years) with a diagnosis of idiopathic hypersomnia (IH) were included in the present study. As a standard treatment, 200 mg/day modafinil was administered to each patient. The P300 auditory test was performed for each patient before and at the end of 1 week of modafinil treatment.ResultsAfter 1 week of modafinil treatment, mean P300 latencies (at all electrode sites) were significantly lower than the latencies before the treatment (P values for Fz, Cz and Pz recording sites were 0.039, 0.002, and 0.004, respectively). An increase in the P300 amplitudes was detected only at the Fz recording site, but not at Cz or Pz recording sites (P values for Fz, Cz, and Pz recording sites were 0.014, 0.100, and 0.05, respectively).ConclusionsOne week of modafinil treatment improved the cognitive performance, alertness, and executive functions in IH patients. Our electrophysiologically obtained findings provide further confirmation for previous reports in which modafinil has been shown to exert favorable effects on cognitive performance, alertness, and executive functions.

Objective: Toxoplasma gondii infection is a very common parasitic disease in human. In Turkey, the rate of seropositivity was reported as 23.1% to 36%. Because of the high affinity of parasite into Central Nervous System (CNS), chronic toxoplasma infection has been found correlated with many neuropsychiatric disorders, including altered mental status, obsessive-compulsive disorder, cognitive impairment, epilepsy, headache and schizophrenia. In this study, we aimed to investigate whether T. gondii has any role in Multiple Sclerosis (MS) by measuring anti-T. gondii IgG antibodies. Methods: Fifty-two MS patients followed up and 45 controls with similar age and socioeconomic status were included in the study. Anti-T.gondii IgL antibodies of the patients and controls were studied in blood with micro-enzyme-linked immunosorbent assay (ELISA) technique. Results: Of 52 MS patients included in the study, 37 had RRMS, 10 PPMS and 5 SPMS. Mean age of onset of the disease was 31.7±10.4 (min; 14 and max; 53). Twenty three of 52 (44.2%) cases with MS and 11 of 45 (24.4%) healthy controls were positive for anti-T.gondii IgG antibodies. There was a statistically significant difference between the rates of positivity between the MS patient group and control group (p=0.042).Conclusion: This study shows a relation of chronic T. Gondii infection with MS. According to this study, experienced T.gondii infection may be one of the several environmental risk factors for MS. ÖZET Amaç: Toxoplasma gondii enfeksiyonu insanda görülen çok yaygın bir paraziter hastalıktır. Türkiye'de seropozitiflik oranı% 23.1% 36 olarak bildirilmiştir. Kronik toxoplazma enfeksiyonu, parazitin Santral Sinir Sistemine'ne (SSS) yüksek afinitesi olduğu için; obsesif-kompulsif bozukluk, bilişsel bozukluk, epilepsi, baş ağrısı ve şizofreni dahil olmak üzere, birçok nöropsikiyatrik hastalıklar ile ilişkili bulunmuştur. Bu çalışmanın amacı, T. gondiyle ilişkili anti-T gondii IgG antikorlarını ölçerek Multipl Sklerozda (MS) her hangi bir rolü olup olmadığını araştırmaktır. Yöntem: Çalışmaya 52 MS hastası ve benzer yaş ve sosyoekonomik statüye sahip 45 kontrol hastası çalışmaya dahil edildi. Hasta ve kontrol grubu kanlarında (ELISA) tekniğiyle immunosorbent assay mikro-enzim-bağlantılı anti-T.gondii IgG antikorları incelendi. Çalışmaya dahil edilen 52 MS hastasının 37'si RRMS, 10'u PPMS ve 5'i SPMS idi. Bulgular: Hastalığın başlangıç yaş ortalaması 31.7±10.4 (min, 14 ve maksimum; 53) idi. 52 MS hastasının 23'ünde (% 44.2) ve 45 sağlıklı kontrol grubunun 11'inde (%24.4) anti-T.gondii IgG pozitifliği vardı. MS hasta grubu ve kontrol grubu (p= 0.042) arasındaki pozitiflik oranları karşılaştırıldığında istatistiksel olarak anlamlı fark vardı. Sonuç: Bu çalışma, MS ile kronik T. gondii enfeksiyonu arasındaki ilişkiyi göstermektedir. Bu çalışmaya göre T.gondii enfeksiyonu, MS için çeşitli çevresel risk faktörlerinden biri olabilir. Anahtar kelimeler: Multipl skleroz, Toxoplasma Gondii, kronik enfeksiyon, otoimmünite Eur J Gen Med 2016; 13(1): 58-63 Toxoplasma Gondii exposure...

ÖZTedavi edilebilir polinöropatilerden olan Kronik İnflama-tuar Demiyelinizan Poliradikülonöropati (KİDP) bazen hızlı progresyon gösterebilir ve kranial sinir tutulumları da tabloya eklenebilir. Yapılan çalışmalarda bu tanı ile izlenen hastaların % 6-15'inde başta fasial sinir olmak üze-re diğer kranial sinir tutulumları saptanmıştır. Olgu sunumu yaptığımız 37 yaşındaki erkek hastada bacaklarda uyuşma ve güçsüzlük şikayetiyle başlayıp 3 yıl içinde hızlı progrese olan klinik tabloya kranial sinir tutulumlarının eklendiği saptandı. Labaratuar ve elektrofizyolojik değer-lendirme ile hastaya KİDP tanısı kondu. Bu olguda KİDP hastalığının seyri sırasında kranial sinir tutulumunun da gözlenebileceği vurgulanmak istenmiştir.Anahtar Kelimeler: Kronik inflamatuar demiyelinizan poliradikülonöropati, Kranial sinir tutulumu, fasial dipleji ABSTRACTCan be treated polyneuropathy for treatment of chronic inflammatory demyelinating polyradiculoneuropathy sometimes shows rapid progression, cranial nerve involvement be added to table. In studies of patinets with diagnosis of facial nerve at 6% to 15%, other cranial nerve involvement were identified. A case report of our 37 years -old male patient who had numbness and weakness in legs, stating with complaint of 3 years according to studies, clinical presentation depends cranial nerve was added, patient with CIDP was diagnosed with laboratory and electrophysiological evaluation. In this case, cranial nerve involvement in CIDP be observed during course of disease is emphasized.