Coronary vessel disease (CVD) is a class of diseases that impacts the blood vessels and heart and is one of the leading causes of disability and death. CVD includes cerebrovascular disease and coronary heart disease, both illnesses of the vessels transporting the oxygenated blood to the brain or heart. Colchicine is an inexpensive and old drug with strong anti-inflammatory effects. Numerous randomized control trials (RCTs) have demonstrated the effectiveness of low-dose colchicine for the prevention of severe cardiovascular events without showing any signs of serious adverse effects within the regime of treatment. In the current meta-analysis, we aim to assess the efficacy and safety of colchicine for secondary cardiovascular outcome prevention among patients with clinically proven CVD. The current meta-analysis was carried out using the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. PUBMED, Cochrane, and EMBASE databases were used to search for RCTs comparing colchicine and placebos for the prevention of secondary cardiovascular outcomes. The primary efficacy endpoint was mortality due to cardiovascular disease, stroke, urgent coronary revascularization, and myocardial infarction. Secondary efficacy outcomes included death due to all-cause mortality. Seven RCTs were reviewed, with a pooled sample size of 12114, out of which 6099 were randomized to the colchicine group, and 6015 were randomized to the control group. The decrease in cardiovascular events, including myocardial infarction, stroke, urgent coronary revascularization, and cardiac-related death, was significantly lower in patients randomized to colchicine (p-value<0.05). The incidence of safety outcomes did not vary significantly different between groups (p>0.05). In patients with CVD, compared to standard medical therapy, colchicine significantly decreases the risk of cardiovascular events such as cardiovascular-related death, myocardial infarction, stroke, and urgent coronary revascularizations.

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This paper illustrates a novel approach to determine the probabilistic rutting in asphalt mixtures based on Weibull distribution statistical approach. In this paper, thirty wearing course asphalt mixtures prepared using different binder grades and aggregate sources, are analysed. Cooper Wheel tracker Test (CWTT)and Asphalt pavement analyser (APA) have been used to ascertain the rutting potential of asphalt mixtures with varying binder grade and aggregate source. Mixtures are then ranked based on their rutting susceptibility. The obtained data is processed using two parametric Weibull approach. Scale and shape parameters are figured out by multiple regression technique. Test results are analysed using goodness of fit test. Results indicate that rut depth predicted from two parameter Weibull distribution technique corelates well with the actual rut depth with R2 value of 0.88 for both cooper wheel tracker and asphalt pavement analyser test. It has been found that Weibull distribution bests fit the NHA-A, NHA-B and SP-B graded mixtures with NRL 60/70 at 50°C. A good correlation has been observed between Cooper Wheel tracker and Asphalt pavement analyser as translated by R2 of 0.86. This research is important in a sense that several agencies have adopted rutting as a failure criteria for flexible pavements. By mathematically modelling the rutting response, predicting the rutting behaviour of mastics becomes simpler and more efficient in approach.

Rationale: Lymphangiomas are lymphatic malformations most commonly found in the head, neck and axilla. Their incidence in gastrointestinal tract, especially duodenum is very rare. They are mostly congenital and are usually seen in children. Owing to their asymptomatic nature, these tumors are often diagnosed incidentally. Surgical resection is the definite treatment. Patient concerns: We represent a case of a 30-year-old male with duodenal lymphangioma with presentation of intermittent dyspepsia for 1 year, partially relieved by a proton pump inhibitor. Diagnoses: Upon physical examination, there was mild tenderness observed in the epigastrium. The rest of the physical examination was unremarkable. His complete blood count report was unremarkable. Upon a negative stool for Helicobacter pylori antigen test, the patient underwent an esophagogastroduodenoscopy which revealed H pylori gastritis and a duodenal lymphangioma. Interventions: Patient was put on triple therapy (clarithromycin, amoxicillin and omeprazole) for 14 days and his symptoms improved. The lymphangioma was not resected owing to small size. Outcomes: Patient was followed till 1 year and his symptoms had improved. Lessons: The case describes a correlation between H pylori gastritis and a duodenal lymphangioma. There is likely to be an association between the two and therefore, further studies are required to find out any relationship that may exist between the 2 conditions.

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