Background: Pregnancy continues to be an event full of risks, complications and adverse outcomes for women despite advanced clinical and diagnostic methods and treatment options available in medicine. Diabetes, as a multifactorial and complex disease, is a possible outcome of a blend of numerous genetic variants of differing scarcities. The exact etiology of gestational diabetes mellitus (GDM) is unclear; however, the interaction of genetic and environmental factors, especially the genetic variants identified as the genetic loci for type 2 diabetes as candidate genes for GDM. Methodology: It will be a case-control study with a genetic analysis of single nucleotide polymorphisms (SNPs) of candidate genes expressed using real-time PCR with sequencing. The study will also evaluate the primer sequence of SNPs. Discussion: We will be able to share the findings after the completion of our research. The results of this study will able helpful in addressing the psycho-physiological needs of women with GDM, which may also be used to devise strategies to benefit the sustainable long-term behavioural change following the affected pregnancy.
<b>Objectives:</b> This study was conducted to investigate the poor sleep hygiene practices of medical students, causing sleep deprivation, and any negative effects on physical and cognitive health of the adult population in Karachi.<br /> <b>Participant:</b> The participant for this study were the medical students enrolled in six medical colleges in Karachi during 2021-2022.<br /> <b>Methods</b>: The data was collected from 200 medical students using questionnaire based survey. Data was analysed using SPSS version 20. t-test and Chi-square (χ2) test was used for the best data analysis. P-value of <0.05 was considered statistically significant in case of comparative analysis.<br /> <b>Results:</b> The majority students did not follow sleep hygiene protocols. Concerning the psychological and cognitive effects of poor sleep hygiene practices, more than 76% participants reported feeling sleep deprived, and experienced physical symptoms.<br /> <b>Conclusion:</b> Our findings support the use of sleep-hygiene awareness as a prevention strategy to improve university students’ sleep practices, preventing sleep deprivation.
<b>Background:</b> Diabetes is a hyperglycemic disease caused by a lack of action of insulin, but serum lipids are also strongly affected by insulin. Serum lipid abnormalities (dyslipidemia) are frequently observed in diabetic populations regardless of insulin deficiency or insulin resistance. Hypertriglyceridemia is the greatest common serum lipid abnormality in diabetic populations. To study the effect of mango seeds on dyslipidemia in diabetes-induced rats. There was a noticeable difference in the body weight (BW) of male and female diabetic rats.<br /> <b>Materials and methods:</b> To investigate effect on BW and the antihyperlipidemic actions of ethanolic extract of mango seed (EEMS) on alloxan-mediated diabetic Sprague-Dawley rats. Antihyperlipidemic in addition antidiabetic properties of an EEMS was planned at 100 and 200 mg/kg BW. The antidiabetic effect of EEMS been matched with tolbutamide 500 mg/kg BW. The lipid levels and BW of male and female rats were examined at consistent periods throughout the research.<br /> <b>Results:</b> The outcomes displayed that the dyslipidemia was considerably decreased in the different treatment groups, while matched with control, the animals cured with tolbutamide and EEMS control.<br /> <b>Conclusion:</b> EEMS exhibited a noteworthy antihyperlipidemic actions in addition with marked difference on BW of both male and female in alloxan-induced diabetic rats.
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