Aim This study determines the impact of traditional and interactive learning activities on personal and professional development among Saudi intern nurses. Design A comparative research design was adopted by recruiting 48 intern nurses, who were divided into two equal groups. Methods Data were collected through the clinical assessment tool for nursing education. Results Enthusiasm ( p < .0001), initiative ( p < .0001), realistic self‐confidence ( p < .0001), competent cooperation with staff ( p < .0001) and competent cooperation with patients ( p < .0001) were significantly higher among the interactive learning activity group compared with traditional group. The interactive learning activity showed better attitude of Saudi intern nurses in terms of caring, respect and sensitivity towards the needs and well‐being of their patients, while considering personal factors.