: Blood and its products play an undeniable role in human life. In recent years, although both academics and practitioners have investigated blood-related problems, further enhancement is still warranted. In this study, a mixed-integer linear programming model was proposed for local blood supply chain management. A supply network, including temporary and fixed blood donation facilities, blood banks, and blood processing centers, was designed regarding the deteriorating nature of blood. The proposed model was applied in a real case in Urmia, Iran. The numerical results and sensitivity analysis of the key model parameters ensured the applicability of the proposed model.
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