A practical, versatile and Metal-free regioselective C5-cyanoalkylation of the 8-aminoquinolineamides/sulfonamides with acetonitrile has been described.
An efficient method for direct thiolation of anilides with thiols using NiCl2·6H2O as the catalyst is developed. Using this method, the desired products were successfully synthesized in moderate to good yields. Initial mechanistic studies suggest that this reaction proceeds through a radical pathway.
The stilbenes are undoubtedly one of the most significant moieties in various bioactive natural and synthetic structures, and they are considered as the privileged structures. Hence, preparation of such structures...
Preparation of many kinds of N-, O-, and S-heterocycles from aryl/alkyl alkynyl aldehydes were investigated in recent years. In this review, the synthesis of bioactive heterocycles using by substituted alkynyl aldehydes is highlighted.
In this work, new applications of one solid acid, nano silica boron sulfuric acid (NSBSA) as a dual Brønsted/Lewis acid in Baeyer-Villiger (B-V) oxidation of ketones with hydrogen peroxide has been introduced; which, because their very small size and large surface area, can improve the capability of this heterogeneous catalyst and promote the B-V oxidation process. The synthesized nano matter was characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy and FT-IR. It was found that the H 2 O 2 /NSBSA system showed good efficiency in the B-V oxidation of alicyclic, aliphatic and aromatic ketones to either esters or lactones. The effects of reaction conditions, such as amount of catalyst, reaction temperature, reaction time and different solvents on the catalytic performance of NSBSA were also investigated. Notably, the process has advantages such as mild reaction conditions, simple operation and high product yield. To the best of our knowledge, the use of the H 2 O 2 /NSBSA system in B-V reactions has never been reported. It should be pointed out that H 2 O 2 , as an environmentally benign oxidant, produces water as the safest by-product and NSBSA can also be recycled and reused for several times without extremely loss of its catalytic activity.
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