Introduction: Coronary artery disease (CAD) is one of the most common causes of morbidity and mortality in developed countries. SYNTAX (SX) score is a useful index that scores lesion severity during coronary angiography (CA) and can predict the patient’s outcome. Recent studies have associated a number of serum parameters with SX score, including platelet volume, and platelet-to-lymphocyte ratio (PLR). Objectives: We aimed to study the SX score in association with various serum parameters to find a valuable parameter for prediction of CAD severity. Patients and Methods: This study consisted of 363 patients referred to Heshmat hospital (Rasht) from March 2016 to October 2016 with acute coronary syndrome (ACS). Serum laboratory parameters were measured after 12 hours of fasting. Severity of CAD was evaluated during CA by SX score. The associations were analyzed using multinomial logistic regression model. Results: The mean age of patients was 63.68±11.03 years; since 26.2% of cases had severe, 43% had moderate, and 30.8% had mild CAD. Comparing to mild CAD, the multivariate adjusted model showed higher significant odds of severe CAD for one elevation of platelets (odds ratio [OR] =2.18 (95% CI: 1.35-3.50), white blood cells (WBCs) (OR=1.66, 95% CI: 1.17-2.35) RDW (red cell distribution width), (OR=1.59, 95% CI: 1.08-2.35) and serum creatinine (OR=1.75, 95% CI: 1.16-2.63). Conclusion: Plasma platelets, WBC and RDW and also serum creatinine were all independently correlated with severity of CAD.
is an aminoglycoside antibiotic. Despite its clinical effects, its application has been restricted due to adverse side effects. The application of this antibiotic is a prevalent cause of acute renal failure in about 10 to 20% of the consumers. 1 Apart from the renal effects, GM also has hepatic effects that induce apoptosis and increase the activity of the reactive oxygen species (ROS). 2 Acute hepatic deficiencies caused by medication are associated with the rapid loss of hepatic function as well as high mortality rate. Currently, for the advanced conditions of the disease, the only alternative is the liver transplantation which due to the shortage of donors and rejection problems presents itself as a huge challenge. 3 However, in recent years, cell therapies utilizing stem cells-due to their inherent ability to repair damaged tissues and organs-have shown remarkable progress in advancing the recovery of damage and disability of organs and tissues. 4 Having said that, the use of stem cells and their administration to patients entail serious risks and side effects such
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