A handful of work focused on improving
the intrinsic low mechanical
properties of hydroxyapatite (HA) by various reinforcing agents. However,
the big challenge regarding improving mechanical properties is maintaining
bioactivity. To address this issue, we report fabrication of apatite-based
composites by incorporation of alumina nanoparticles (n-Al2O3). Although numerous studies have used micron or submicron
alumina for reinforcing hydroxyapatite, only few reports are available
about the use of n-Al2O3. In this study, spark
plasma sintering (SPS) method was utilized to develop HA-nAl2O3 dense bodies. Compared to the conventional sintering,
decomposition of HA and formation of calcium aluminates phases are
restricted using SPS. Moreover, n-Al2O3 acts
as a bioactive agent while its conventional form is an inert bioceramics.
The addition of n-Al2O3 resulted in 40% improvement
in hardness along with a 110% increase in fracture toughness, while
attaining nearly full dense bodies. The in vitro characterization
of nanocomposite demonstrated improved bone-specific cell function
markers as evidenced by cell attachment and proliferation, alkaline
phosphatase activity, calcium and collagen detection and nitric oxide
production. Specifically, gene expression analysis demonstrated that
introduction of n-Al2O3 in HA matrix resulted
in accelerated osteogenic differentiation of osteoblast and mesenchymal
stem cells, as expression of Runx-2 and OSP showed 2.5 and 19.6 fold
increase after 2 weeks (p < 0.05). Moreover, protein
adsorption analysis showed enhanced adsorption of plasma proteins
to HA-nAl2O3 sample compared to HA. These findings
suggest that HA-nAl2O3 could be a prospective
candidate for orthopedic applications due to its improved mechanical
and osteogenic properties.
The primary aim of this study is the beneficiation of magnesite ores from eastern part of Iran by reverse flotation process. For this purpose, the mineralogical and microstructural characteristics of the as-received and the processed ores from Iranian Afzal Abad mine were established. The liberation degree of ore was estimated at about 75 µm. Then the as-received ore and the processed one were dead burnt to produce magnesia aggregates. These aggregates were used for production of shaped and unshaped refractories. Bricks and monolithic ramming mixes which were made from these aggregates were analysed and their mechanical and physical properties, studied. The results of this investigation showed that the application of reverse flotation process on the magnesite ore of eastern part of Iran causes an acceptable reduction on the amount of its siliceous inclusions, so that this type of the processed magnesia is suitable for utilization in the refractory industries. The magnesia produced from the original calcined ore was not suitable for this industry due to the presence of unacceptable amount of siliceous inclusions, which make its properties very poor.
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