Background: Acne is a multifactorial skin lesion and a persistent inflammatory disorder of the pilosebaceous units. One of the most common skin problems, acne vulgaris, which predominantly affects teenagers but can affect anyone at any age, is treated by dermatologists. Objective: The goal of the current study was to assess the profile of changes in ALT, AST, and lipid profiles (TGs, LDL, and HDL) in these patients. Methodology: This cross-sectional study was conducted at tertiary care hospital Dhaka District from June 2020 to July 2022 in the Department of Dermatology. A total of 200 patients were participate in the study. Patients aged more than 15 years, both male and female and patients with diagnosed acne were included in the study. Severely ill patients and not willing to participate were excluded from the study. Data collection was done after approval of protocol using a semi-structured questionnaire through face to face interview. Data were analyzed using a computer programme SPSS 25.0 version. Result: The mean age of male was 22 (±6.7) while in case of female was 24 (±4.5). Minimum age of the patients was 18 year and maximum was 45 year. 75% of the respondents were female and 25% were male. The mean ((±SD)) RBC was 4.9 (0.5)×106 /mL, WBC was 8.4 (3.5)×103 /mL and Hb was 14.3 (1.7)×106 /mL, in case of female the Hb was 12.6 [1.5]× 106 /mL and 14.9 (1.1)×106 /mL for male. In this present study, we discovered that individuals who received isotretinoin medication was statistically significant increases in both TG and LDL levels. Additionally, we discovered statistically significant decreases in HDL levels. In our study, patients who received isotretinoin treatment had liver enzymes that were less altered than lipids. The clinical classification was unaffected, although there were statistically significant increases in AST levels. ALT levels raised as well, but the variations were not statistically significant. Conclusion: Although severe laboratory alterations
A clinical trial was carried out for the duration of six months from September' 2012 to February' 2013
Alopecia areata is a common, unpredictable, nonscarring form of hair loss. It is characterized by rapid and complete loss of hair in one or more round or oval patches, usually on the scalp, bearded area, eyebrows, eyelashes and less commonly on other hairy areas of the body. The present study was undertaken in the department of Dermatology and Venereology of Ibn Sina Medical College, Dhaka from July 2014 to June 2015 to observe the histopathological changes in different stages of alopecia areata. For this purpose 30 patients with age ranged from 18 to 45 years were enrolled. Of them 17 were males and 13 were females. A 4 mm punch biopsy from the involved scalp taken from each patient and histopatological changes were examined. The study revealed that anagen hairs decreased but catagen and telogen hair increased in all stages of alopecia areata. Telogen hairs increased in acute and chronic stage and catagen hair increased markedly in subacute stage. Although miniaturized (atrophic) follicle was frequently found in chronic stage. It was absent in acute and subacute stages. Moderate to dense peribulbar infiltration of lymphocytes were observed in acute stage and mild to moderate infiltration in subacute stage. In chronic stage either no or mild infiltrations were observed. Peribulbar infiltration of eosinophils and macrophages was seen in all stages of alopecia areata. Thus we can conclude that alopecia areata can be diagnosed with some confidence, even when inflammatory infiltrate is absent, based on increasing numbers of telogen hairs in the acute and subacute stages and increasing miniaturized hairs in chronic stage.Medicine Today 2018 Vol.30(1): 30-33
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