Recent studies have indicated that consumption of amino acid-rich compounds can increase tendon collagen content and enhance biomechanical function. Still, it is not clear as to what extent oral consumption of amino acids alters peritendionus amino acid concentrations. Whether aging alters the delivery of amino acids to tendon tissue after oral consumption is also not known. Using microdialysis, we determined the impact of a single oral essential amino acid bolus on Achilles peritendinous amino acid concentrations in younger (n=7; 27±1 yr.) and older adults (n=6; 68±2 yrs.) over four hours. The peritendinous concentration of all amino acids in the beverage except methionine increased with time (p<0.05). Additionally, the concentrations of methionine, phenylalanine, histidine, and glycine were greater in older adults (p<0.05). The amino acid concentrations in the Achilles peritendinous space were lower than those previously reported in serum or skeletal muscle after a bolus with a similar amino acid content. We also accessed the impact of amino acid consumption on peritendinous concentrations of pro-collagen Iα1, a marker of collagen synthesis. Pro-collagen Iα1 was not altered by the consumption of amino acids or age (p>0.05). We demonstrate that an oral amino acid bolus leads to modest increases in Achilles peritendinous amino acid concentrations in young and older adults. The concentration of several amino acids was also greater in older adults. However, the amino acid bolus did not impact peritendinous pro-collagen concentrations.
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