Objective: To determine the association of haematological parameters with disease complications in patients with type 2 Diabetes Mellitus.
Study Design: Cross-sectional analytical study.
Place and Duration of Study: Department of Hematology, Armed Forces Institute of Pathology, Rawalpindi Pakistan from Feb to Aug 2019.
Methodology: In this study, 200 Patients were selected and divided into four groups, 1) Anaemia without Diabetes 2) Diabetes with Anaemia 3) Diabetes without Anaemia 4) Healthy Control Group. All the patients were assessed because of their clinical history and laboratory evidence. The patients' clinical details, type of anaemia, laboratory investigations and complications related to diabetes were recorded on a specially designed proforma.
Results: Diabetes-related complications were highest in diabetes with anaemia Group. It was recorded that diabetes with anaemia Group, 36 patients (50.0%) had microvascular complications and 32 patients (47.8%) had macrovascular complications. In the healthy control group, 8 patients (11.1%) had microvascular complications, and nine patients (13.4 %) had macrovascular complications.
Conclusion: Patients with type 2 Diabetes Mellitus should be evaluated and treated for anaemia routinely to prevent complications
Objective: To study the diagnostic utility of lactate dehydrogenase levels in differentiating megaloblastic anemia from myelodysplastic anemia in Pakistan.
Study Design: Comparative cross-sectional study.
Place and Duration of Study: Department of Hematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan from Feb, 2019 to Aug, 2019.
Methodology: In this study, total 240 patients (18-75 years of age) males and females were selected by consecutive sampling technique and were equally divided into 3 groups; patients with megaloblastic anemia, patients with myelodysplastic syndromes and healthy control group. The clinical history and duration of anemia were recorded on special designed proforma. The laboratory investigations including lactate dehydrogenase levels were also noted. Both types of anemia were compared on basis of Lactate Dehydrogenase Levels.
Results: The lactate dehydrogenase levels in megaloblastic group were more than 3000 IU/L in 58 out of 80 patients (72.5%). On other hand, myelodysplastic group had 79 out of 80 patients with lactic acid dehydrogenase levels below 450 IU/L (98.75%). The difference in lactic acid dehydrogenase levels between both groups was found to be statistically significant.
Conclusion: Serum lactate dehydrogenase levels can be used to differentiate megaloblastic anemia from other anemia especially myelodysplastic syndromes before doing a bone marrow examination. High lactate dehydrogenase levels above 3000 IU/L in megaloblastic anemia can differentiate it from other anemia.
SummaryRaised cholesterol levels can alleviate the risk of cardiovascular diseases and stroke and are responsible for one‐third of all ischemic heart diseases worldwide. Moringa oleifera (MO) plant has gained nutraceutical prominence; therefore, its lipid‐lowering potential was investigated by its incorporation (leaves MOL, seeds MOS and leaves + seeds MOLS) into cookies. These cookies were then analysed for nutritional, physicochemical and clinical properties. The sensory properties received overall higher acceptability scores of 15% and 25% in MOL followed by MOS and MOLS cookies. Clinical investigations in hyperlipidaemic patients revealed significant reductions in total cholesterol (7.56% and 5.56%), low‐density lipoprotein cholesterol (6.59% and 5.03%) and triglycerides (6.75% and 4.76%) in MOL and MOLS. While a significant increase in the high‐density lipoprotein cholesterol (10.66%, 5.88% and 9.15%) in all three groups was observed, with a more pronounced raise in MOL Cookies. Furthermore, serum biochemistry (AST, ALT, ALP, urea and Creatinine) values remain within normal range revealing the safety for utilisation. The overall results indicated that MO possesses a positive effect on the lipid profile, therefore, can be a part of diet‐based therapy for the attenuation of chronic diseases.
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