A single‐step visible light mediated synthesis of β‐hydroxydithioacetals via oxidative coupling of terminal alkynes with thiophenol is reported. Compared to other multistep strategies, this work presents a rare tandem introduction of disulfides and a hydroxy group at the β‐position in one pot. The reaction is enabled by aerial oxidation, features high efficiency and mild conditions, and is extendable to both aliphatic and aromatic alkynes.
A novel transition metal‐free photosensitized protocol has been developed for the synthesis of α‐ketoamides via oxidative coupling of alkynes and amines in the presence of thiophenol under visible light irradiation and rose bengal dye. A series of alkynes with both electron‐donating and electron‐withdrawing groups were successfully employed for the synthesis of their corresponding α‐ketoamides. This reaction presents a benign visible light based milder synthetic methodology with broad functional‐group tolerance.
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