Background: Oral cancer ranks the sixth commonest cancer worldwide and the third most common cancer in India. Ki67 index has been suggested to play an important role in early diagnosis and prognosis of potentially malignant disorders. This study aims to understand prognostic role of Ki 67 expression in different categories of oral mucosal neoplastic lesions in Central India, where tobacco chewing is endemic. This could help in early categorization and effective management of patients. Aims: To study the Ki67 expression in terms of Index of Positivity and Intensity score in oral mucosal neoplastic lesions. Setting and Design: Department of Pathology, Tertiary Care Hospital Observational & Prospective study Methods & Material: The expression of Ki-67was studied in parafn- embedded tissue sections of histopathology proven pre- malignant and malignant lesions of oral cavity in ninety four cases. Results: Association of Ki67 Expression Intensity score with the type of lesion was found to be signicant in premalignant and malignant lesions predominantly (p= <0.001).Similarly, Ki67 Index of positivity score was highly statistically signicant (p= <0.001) in association with the type of lesion. Conclusions: the expression of Ki-67 correlates well with the disease progression from dysplasia to carcinoma of the oral cavity. It is therefore a marker of malignant transformation and carcinogenesis in oral premalignant lesions and in future it may serve as a prognostic tool in the early detection of malignancy
Background: Morphological diagnosis of leukemias may sometimes not correlate with flow cytometry diagnosis. Classification of hematological neoplasm by the World Health Organization gives priority to cytogenetic, molecular biology, and even patient history, in an attempt to classify patients primarily regarding prognosis. Cytomorphology and immunophenotyping complement each other. Morphology is burdened by a high degree of subjectivity. That is why correlation of information provided by the two techniques is still absolutely necessary. The aim of our study was to correlate between cytomorphological findings and immunophenotyping results on a group of patients investigated for acute leukemia. Materials and Methods: Study was conducted in department of pathology in Chirayu Medical College and Hospital, Bhopal from December 2018 to September 2019. Cases were diagnosed as acute leukemia based on complete blood count and bone marrow aspirate/peripheral smear.These cases were sent to flowcytometry for immunophenotyping for further confirmation. Results: Total 74 cases of acute leukemias were diagnosed, out of which 30 were Acute myeloid leukemia and 44 were Acute lymphoblastic leukemia. There was 95.95% correlation between diagnosis on cytomorphology and flowcytometry. Two cases remain unclassified on cytomorphology which turn out to be Acute myeloid leukemia on flowcytometry. One case of Acute myeloid leukemia on cytomorphology was diagnosed as Acute lymphoblastic leukemia on flowcytometry. Conclusions: Inclusion of flowcytometry in routine diagnostic workup of acute leukemia ensures proper characterization as well as management. Major challenges for the near future are the standardization of technical procedures, data interpretation, and reporting.
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