The methanolic leaf extracts of Carica papaya, Chromolaena odorata, Alcohorneae laxiflora and Elaeis guineensis were investigated for antifungal activity against Penicillium minioluteum JX 442528 and Aspergillus niger JX 442527 in the mycology laboratory of Babcock University, Ilishan remo.. Also, common agro-wastes (wheat bran, rice bran and corn cobs) served as treatments as components of bioreaction for Penicillium minioluteum and Aspergillus niger both in submerged and solid state fermentations. Fungal growth inhibition was recorded with extracts from Carica and Chromolaena spp Extract of Elaeis guineensis extract has the lowest antifungal effect on Penicillium minioluteum. The solid state fermentation has higher enzyme activity compared to the submerged fermentation. Highest production for the 4 enzymes assayed for was observed on wheat bran media, using the SPSS statistical package. For industrial enzyme production, these cultural characteristics could therefore be critical.
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