Due
to self-produced extracellular polymeric substances (EPS),
biofilms are hard to eradicate by common antimicrobials. Herein, a
new quaternary ammonium salt based cross-linked micelle (QAS@CM) was
created to combat biofilms. The QAS@CM adsorbed first onto the biofilm
surface through multicharged interaction, then penetrated the EPS
in the form of nanoparticles and diffused throughout the films. By
responding to the biofilm acid/lipase microenvironment, these nanoparticles
would further break into quaternary ammonium oligomers and act as
the polyvalent inhibitors to effectively destroy the established biofilm
and kill the corresponding bacteria within it.
Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water via coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (1a–c).
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