A mild and efficient dynamic kinetic resolution (DKR) of amines was achieved by combining visible-light-induced photoredox catalysis and enzyme catalysis. This dual catalytic system was appropriate for both monoamines and 1,4-diamines.

Thiocarbonylation of alkenes offers an ideal procedure for the synthesis of thioesters. However, thiocarbonylation of alkenes, especially styrenes, to produce valuable linear thioesters has remained a challenge. In this Letter, a general palladium-catalyzed thiocarbonylation of alkenes to produce linear thioesters has been achieved. Moderate to good yields of desired thioesters can be produced from readily available alkenes in a straightforward manner.

Secondary amides are omnipresent structural motifs in peptides, natural products, pharmaceuticals, and agrochemicals. The copper-catalyzed enantioselective hydroaminocarbonylation of alkenes described in this study provides a direct and practical approach for...

Controllable production of α-keto amides and amides from the same substrates is an attractive goal in the field of transition-metal-catalyzed (double-)carbonylation. Herein, a novel copper-catalyzed highly selective double carbonylation of alkyl bromides has been developed. Moderate to good yields of α-keto amides were obtained as the only products. In the case of alkyl iodides, double-and mono-carbonylation can be achieved controllably under different conditions.

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In this work, am ild and transition-metal-free approach for the nucleophilic aromatic substitution (S N Ar) of unactivated fluoroarenesw ithp rimary aliphatic amines to form aromatic amines is reported. This reactioni sf acilitated by the formationo fc ationic fluoroarene radical intermediates in the presence of an acridinium-based organic photocatalyst under blue-light irradiation. Various electron-rich and electron-neutralf luoroarenesa re competent electrophiles for this transformation. Aw ide range of primary aliphatic amines,i ncluding amino acide sters, dipeptides, andl inear and branched amines are suitable nucleophiles. The synthetic utility of this protocol is demonstrated by the late-stage functionalizationo fs everalc omplex drug molecules.

Herein, we report the first ruthenium-catalyzed Suzuki-type carbonylative reaction of electronically neutral anilines via C­(aryl)–N bond cleavage. Without any ligand and base, diaryl ketones can be obtained in moderate to high yields by using Ru3(CO)12 as the catalyst and chelation assisted by pyridine. The pyridine ring has a significant effect on both high efficiency and high regioselectivity in the cleavage of the aryl C–N bond in anilines.

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