Objective Systematic evaluation of the application of probiotics in the treatment of polycystic ovary syndrome (PCOS).Methods Computer searches of PubMed, The Cochrane Library, Web of Science, Medline, Embase, Ovid, CNKI, Wan Fang Data, and VIP databases were conducted to retrieve RCT studies on probiotics for the treatment of patients with PCOS from the time of database creation to March 2021. Meta-analysis was performed by two researchers after screening, extracting, and evaluating the literature using revman 5.3 software.Results A total of 13 studies were included, and the results of Meta-analysis showed that compared with the placebo group, probiotic supplementation increased sex hormone binding globulin (SHBG) and insulin sensitivity testing index (QUICKI) and decreased fasting insulin (INS), total testosterone (TT), insulin resistance index (HOMA-IR), fasting blood glucose (FPG), low-density lipoprotein (LDL-C), triglyceride (TG), and total cholesterol (TC) levels in PCOS patients (P<0.05); there was no significant effect on deoxyepiandrosterone sulfate (DHEAS), high-density lipoprotein (HDL-C), and hyper-sensitive c-reactive protein (HS-CRP) levels in PCOS patients (P>0.05).Conclusions Probiotics may improve serum levels of endocrine and metabolism-related indicators in patients with PCOS, but further investigation and validation in large samples and high-quality RCT studies are needed.
A new approach to the synthesis of isoindolinones via direct coupling of N‐methoxybenzamides and bis(tosylamido)methane with rhodium(III) as catalyst has been developed. The reaction is performed under mild conditions without oxidant, and is compatible with various functional groups. Compared with the previously reported methods for constructing isoindolinone skeletons, this method involves a novel [3+2] cyclization, and affords a wide variety of isoindolinones in moderate to excellent yields.
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