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As a result of small fault current, high level of noise and a large penetration of distributed generators (DG), in the neutral non-effectively grounded medium-voltage (MV) distribution networks, it is quite difficult to locate the faulted line section for single phase to ground faults. In this paper, using a technique based on synchronized measurements in distribution networks, a fault location method based on the analysis of the energy of the transient zero-sequence current in the selected frequency band (SFB) is proposed. The equivalent impedance of the distribution network with lateral branches is studied with an equivalent network, and the phase-frequency characteristics of the equivalent impedance are analyzed. The SFB, within which the transient energy of the faulty line section is larger than that of the healthy line sections is determined. A combined fault-section location criterion is proposed and the implementation scheme is illustrated with the distribution level phasor measurement units. Numerical simulations of the IEEE 34 node system and the field experiments of a 10kV distribution network validate the feasibility and effectiveness of the proposed method.Index Terms--Active distribution networks, fault location, neutral non-effectively grounded system, single phase to ground faults, transient zero-sequence current.

An electronic density model was developed and used to identify a novel pyrrolotriazinone replacement for a quinazolinone, a commonly used moiety to impart selectivity in inhibitors for PI3Kγ and PI3Kδ. Guided by molecular docking, this new specificity piece was then linked to the hinge-binding region of the inhibitor using a novel cyclic moiety. Further structure–activity relationship optimization around the hinge region led to the discovery of candidate 26, a highly potent and selective PI3Kγ–PI3Kδ dual inhibitor with favorable drug metabolism and pharmacokinetic properties in preclinical species.

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