Lake systems are of fundamental significance for the ecological environment and social development. Driven by climatic changes and human activities, the hydrological situation of rivers and lakes has been altered considerably, and it has directly affected the reliability of irrigation and water supply in lake areas. In the case of the Yangtze River–Dongting Lake area, the quasi-equilibrium of their hydrological states and water balance have been affected by the operation of the Three Gorges Project that has led to irrigation and water supply problems across the lake area. Ever since, the available water supply in the Dongting Lake area has decreased by 31.5% and 47.7% during the months of September and October, and the overall water level in the lake area has dropped by 0.8–2.0 m. The proportion of domestic and agricultural irrigation water demands to available water supply in the Dongting Lake area is very small, and the decline of water level is the main reason for the lack of water supply in Dongting Lake area, Although the total amount of water in the lake area is still above the water supply threshold, an obvious decreasing trend has been observed in the fulfillment of the demand for both irrigation and water supply in urban and rural regions. Additionally, the fulfillment of secured water supply and irrigation requirements has respectively dropped from 95% to 78% before the operation of the Three Gorges Project to 82% and 46% after it. Meanwhile, the total water shortage increased from 57.683 to 143.607 million cubic meters. By advancing or postponing impoundment schedules, the impact of the Three Gorges Reservoir on irrigation and water supply in the lake area during September and October can be alleviated, and the water supply capacity can be respectively increased by approximately 1.3% and 1.4%. The highlights of this study include the quantification of the impacts of the operation of large-scale water conservancy projects at the level at which the requirements on irrigation and water supply in the lake area are satisfied, and the prediction of the trends for future evolvement. In addition, corresponding strategies that provide a technical reference for the comprehensive regulation and control over water resources and the security of water supply in the river basin are discussed.
Objective Human epithelial growth factor receptor 2 (HER2) is overexpressed in several types of cancers. The correlation between tumor glucose activity and HER2 expression can vary. This study is a retrospective investigation of fluorine-18-fluorodeoxyglucose PET/ computed tomography ( 18 F-FDG PET/CT) and HER2 expression status in patients with lung adenocarcinoma.
MethodsThe maximum standard uptake value (SUV max ) of 18 F-FDG PET/CT was compared with the HER2 expression status in pretreated patients with lung adenocarcinoma. Moreover, clinicopathological characteristics, including age, gender, smoking, serum tumor markers, tumor location, size, stage and genetic mutation, were also evaluated in groups with different HER2 expressions. Patients' progression-free survival (PFS) and overall survival (OS) were also analyzed.
ResultsNinety-six patients with HER2 expression, including 54 patients with HER2 overexpression and 30 patients without HER2 expression were enrolled in this study. The primary pulmonary lesion was single in all patients, and all lesions were FDG-avid on PET/CT. SUV max had no significant association with HER2 expression or overexpression in lung adenocarcinoma. Moreover, elevated serum CYFRA211 levels were obviously associated with HER2 expression but not associated with HER2 overexpression. There were no significant differences in other clinicopathological characteristics in groups with different HER2 expressions. Furthermore, multivariate Cox regression analysis revealed that SUV max , HER2 expression and tumor node metastasis stage were independent predictors of PFS, and SUV max , CYFRA211 and epidermal growth factor receptor mutation were independent predictors of OS.Conclusion SUV max had no significant association with the HER2 expression status in lung adenocarcinoma. 18 F-FDG PET/CT and HER2 expression could provide valuable prognostic information for treatment-naive patients with lung adenocarcinoma. Nucl Med Commun 43: 442-450
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