Cyclooxygenase (COX)-2 inhibitors are known to be used as chemopreventative agents against certain malignancies. Thus far, there has been very limited information on whether COX-2 inhibitors protect against chronic narrow-band UVB (NB-UVB)-induced immunosuppression. The present study investigated the effect of nonselective and specific COX-2 inhibitors, indomethacin and celecoxib, on epidermal Ia+ Langerhans cells (LCs) and Thy-1+ dendritic epidermal T cells (DETCs) in mice irradiated with NB-UVB. Sixty female BALB/c mice were divided randomly into the control group (sham) and the experimental groups (irradiated with NB-UVB for 17 weeks, further divided into five groups according to the diets containing different concentrations of either COX-2 inhibitors). Alterations in the density and morphology of epidermal Ia+ LCs and Thy-1+ DETCs in mice were documented using fluorescence microscopy. Chronic NB-UVB irradiation substantially decreased the density and altered the morphology of the epidermal Ia+ LCs and Thy-1+ DETCs in control mice. The dietary supplementation of both COX-2 inhibitors displayed a dosage-dependent protective effect on the murine dendritic cells irradiated by NB-UVB. In conclusion, COX-2 inhibitors protected against chronic NB-UVB-induced density and morphologic changes in epidermal Ia+ LCs and Thy-1+ DETCs in mice.
It is difficult to accurately identify dispersion curves of Rayleigh wave for the foundation with obstacles. Displacement curve of time-domain of half-space foundation have been obtained with the finite element in the paper. Then time-domain curve have been transformed Rayleigh wave dispersion curves. Rayleigh wave dispersion curves have been analysed in half-space foundation with water drain pipes. The results show that, there are reflection waves at the receiving signals in front of the obstacles, there are no reflection waves behind the obstacles basically. The location and spacing of the sensor have a greater impact on the results. The results provide the reference for the recognition of dispersion curves and disposition patterns of the sensors.
The horizontal vibration characteristic of the pile foundation is a key technology in dynamic design of foundation engineering. By researching on the horizontal harmonic loads in layered foundation, use horizontal vibration answers of buried foundation to deal with horizontal vibration impedance problems of pile tip. The transition matrix can be used to analyze the dynamic impedance function for horizontal vibration of pile foundation in layered foundation. And results in the paper is checked with traditional methods, which shows the both results fitting well.
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