Given the essential role of prolactin (PRL) and its receptor (PRLR) in breast tumorigenesis, we investigated whether single nucleotide polymorphisms (SNPs) in the PRL and PRLR genes were associated with breast cancer in Taiwanese women. A total of 160 breast cancer patients and 336 unrelated control Taiwanese women were enrolled in this study. Three SNPs (rs1341238, rs2244502 and rs3756824) in the PRL gene and one SNP (rs10941235) in the PRLR gene were genotyped using allele-specific polymerase chain reaction and DNA sequencing. We showed that the PRLR SNP rs10941235 was associated with breast cancer (P < 0.05) and its genotype frequencies in the breast cancer group were significantly associated (P < 0.05) with the levels of cancer antigen 15-3, a serum biomarker of breast cancer. The PRL SNP rs3756824 was significantly associated with breast cancer metastasis (P < 0.05). These findings suggest that the polymorphism rs10941235 in the PRLR gene is associated with breast cancer and cancer antigen 15-3 levels in Taiwanese women.
Introduction: The incidence of splenic cysts is low, and most are asymptomatic. Symptomatic splenic cysts have rarely been reported. Due to the unspecific clinical and radiologic features, the nature of a cyst is difficult to define in the absence of a history of trauma. Therefore, splenectomy is usually the treatment of choice for obtaining a specimen. In particular, total splenectomy has been the treatment of choice for removal of splenic cysts. Case Presentation: A 25-year-old male patient visited the outpatient department at Tri-Service General Hospital Penghu Branch, Taiwan, with the chief complaint of abdominal fullness. No obvious history of trauma was reported. A series of examinations were performed, and abdominal computed tomography showed one large splenic cyst within the splenic septum. We performed single-incision laparoscopic splenectomy, and the patient recovered well and returned to daily activities one week later. Conclusions: In this modern era of minimally invasive surgery, laparoscopic surgery has reduced postoperative pain and improved recovery, with no increase in complications. Laparoscopic splenectomy has become the trend for the management of splenic cysts. Although single-incision laparoscopic surgery is a technical challenge, better cosmetic results and decreased postoperative wound pain are considered to be superior outcomes compared with those of conventional multi-port laparoscopic surgery.
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