ABSTRAKPenelitian ini bertujuan untuk melakukan analisis hubungan kuantitatif antara struktur dan aktivitas analgesik senyawa turunan meperidin dan menentukan persamaan Hansch antara senyawa turunan meperidin dengan aktivitas analgesiknya. Penelitian dilakukan melalui perhitungan komputer (in silico) dengan menggunakan metode semiempiris AM1. Tahap pertama yaitu melakukan pemodelan molekul senyawa turunan meperidin, kemudian melakukan proses optimasi geometri. Langkah kedua yaitu melakukan pencarian nilai deskriptor yang berupa deskriptor elektronik, sterik, dan hidrofobik. Tahap terakhir dilakukan analisis statistik menggunakan regresi berganda model Backward. Hasil penelitian menunjukkan bahwa aktivitas analgesik dipengaruhi secara signifikan oleh variasi deskriptor, terutama deskriptor elektronik yang memiliki pengaruh lebih dominan daripada deskriptor sterik dan hidrofobik. Deskriptor yang paling berpengaruh adalah muatan pada atom N, karena atom N merupakan komponen penting dalam senyawa analgesik. Kata kunci: turunan Meperidin, aktivitas analgesik, deskriptor elektronik, persamaan Hansch ABSTRACTThis research aims were to analize a quantitative relationship between the structure and analgesic activity of meperidine derivatives and to determine the Hansch equation between meperidine derivatives and their analgesic activity. The study was done by computer calculation (in sillico) using semiempirical method of AM1. The first stage was molecules modelling of meperidine derivative compounds, followed with performing the process of geometric optimization. The second step was to determine the descriptor value in the form of electronic, steric, and hydrophobic descriptors. The last stage was done by statistics analysis using multiple regressions with backward model. The results showed that analgesic activity was significantly influenced by variation of descriptors, especially electronic descriptor which has more dominant influence than steric and hydrophobic descriptors. The most influential descriptor is the charge on N atoms, since N atoms are an important component in analgesic compounds.
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