In this work, we report the antioxidant and free radical scavenging activity of 6-bromoeugenol and eugenol. EC50, the concentration providing 50% inhibition, is calculated and the antioxidant activity index (AAI) is evaluated. The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging method. EC50 values of 6-bromoeugenol, ascorbic acid and eugenol were 34.270 μg/mL, 54.888 μg/mL and 130.485 μg/mL, respectively. 6-Bromoeugenol showed higher AAI value (1.122) followed by ascorbic acid (0.700), then by eugenol (0.295). We also investigate the kinetics of DPPH radical scavenging activity of our products to determine the useful parameter TEC50 to evaluate their antiradical efficiency (ARE). Our results have shown high ARE. This study has provided the following ARE ( × 10(-3)) order for the tested antioxidants: ascorbic acid (70.119)>6-bromoeugenol (34.842) > eugenol (21.313). Finally, we classify ascorbic acid and eugenol as fast kinetics reaction (TEC50 8.82 and 11.38 min, respectively) and 6-bromoeugenol as medium kinetics reaction (TEC50 39.24 min).
We have studied the antimicrobial properties of 6-bromoeugenol and eugenol by three strains: Pseudomonas aeruginosa (S1), Escherichia coli (S2) and Staphylococcus aureus (S3). We have determined the minimum inhibitory concentration (MIC) for a range of concentrations using the disc diffusion method. We note that all samples present an antimicrobial activity toward the tested bacterial strains at different concentrations (1, 0.5 and 0.25 mg/ml). The 6-bromoeugenol gives modest activity with (S1) and (S3). Eugenol reacts positively with the Pseudomonas aeruginosa (S1) at all concentrations and with the Escherichiacoli (S2) at 0.5 mg/ml. We remark that the Pseudomonas aeruginosa (S1) is the more sensitive strain than Escherichiacoli (S2) and Staphylococcus aureus (S3). We have estimated the activity coefficient which has confirmed the antimicrobial activity of the different samples. So, 6-bromoeugenol has shown his efficiency as antimicrobial agent.
Re ´sume Ćetravail consacre ´aux oxophosphonates, concerne trois classes de produits : les a-ce ´tophosphonates, les b-ce ´tophosphonates, et enfin les get d-ce ´tophosphonates que nous avons regroupe ´s en une seule classe. Pour chaque classe, nous avons e ´voque ĺes diffe ´rentes me ´thodes de synthe `se ainsi que leur re ´activite ´. Dans cette dernie `re partie, nous avons de ´veloppe ´les diffe ´rentes me ´thodes de re ´duction, les re ´actions d'addition nucle ´ophile et les re ´actions de substitution par les he ´te ´roatomes. Nous avons particulie `rement mis l'accent sur les de ´rive ´s soufre ´s et amine ´s et les de ´rive ´s fluore ´s et chlore ´s.
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