This interventional study with historical controls was conducted to study the effect of cephalosporin restriction on the incidence of extended spectrum beta-lactamase (ESBL) gram negative infections in neonates admitted to intensive care unit. All gram negative isolates from the blood were evaluated for beta lactamase production. The incidence of ESBL production was compared before (year 2007) and after cephalosporin restriction (year 2008). Thirty two neonates (3% of NICU admissions) in the year 2007 and fifty six (5.2%) in the year 2008, had gram negative septicemia. The incidence of ESBL gram negatives decreased by 22% (47% to 25%, P=0.03). Restriction of all class of cephalosporins significantly decreased the incidence of ESBL gram negative infections.
Proton pump inhibitors (PPIs) are the widely used class of drugs for the treatment of gastric acid-related disorders and also used in almost all types of prescription. PPIs inhibit gastric acid secretion by inhibiting the potassium ATPase, which is responsible for acid production. An investigation was carried out on PPIs inducing an adverse effect cytopenia in wistar albino rats. Two drugs namely omeprazole and rabeprazole had been selected for the investigation. Rats had been divided into two groups as normal group and control group. Control group is further divided into two groups as omeprazole control group and rabiprazole control group. Normal group received saline water and control group received omeprazole (40mg/kg) and rabeprazole (20mg/kg) by PO respectively, for a period of one month. Blood was collected after 30 days of continuously administration of drugs by retro orbital puncture. Blood sample of normal and control groups had been analyzed for complete blood picture (CBP). The data was analyzed by using ANOVA followed by Dennett’s multiple comparison. The results are significant at a level of P<0.05
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.