ABSTRACT:The preparation and production of multilamellar liposomes from Soya lecithin with 75% phosphatidylcholine were carried out and the behavior of liposomes in dye-bath at different temperature, time, and concentration were examined. It was found that liposomes with concentration of below 3% o.w.f. (on weight of fabric) in the dye-bath increases the amount of K/S for the samples dyed at 858C or below 858C for 60 min. Dyeing of wool at higher temperature and longer time with higher concentration of liposomes reduces the color strength. The results showed that using 2% o.w.f. of liposomes in dye-bath at 858C for 60 min improves the K/S. The Central Composite Design is used for the experimental plan with three variables on the results of color strength. Statistical analysis confirms the optimum conditions obtained by the experimental results. It was also found that wash, light, wet and dry rub fastness properties of samples dyed with madder including liposomes have not changed significantly.
Cu(ii) immobilized on deferasirox loaded amine functionalized magnetic nanoparticles (Cu(ii)/FeO@APTMS-DFX) as a novel magnetically recyclable heterogeneous catalyst is able to catalyze the [3 + 2] cycloaddition reactions of various organic nitriles with sodium azide. Using this method, a series of 5-substituted-1-tetrazoles under mild conditions in DMSO were prepared. The reaction involves mild reaction conditions with efficient transformation capability. The developed catalyst could be easily separated by applying an external magnetic field. Furthermore, it could be recycled for 5 runs with negligible leaching of copper from the surface of the catalyst. The catalyst was characterized by various techniques such as FT-IR, TGA, VSM, SEM-EDX, and ICP-OES. Several derivatives of 1-tetrazoles were prepared using this catalyst, and their structures were confirmed using different techniques. Then, the synthesized anthraquinones were evaluated for their cytotoxicity against several cell lines including MCF-7, MAD-MD-231, HT-29, HeLa, neuro-2a and L-929. The results obtained from the MTT assay revealed that the 6 derivatives exhibited a high level of cytotoxicity. In order to determine the cytotoxicity mechanism, 2 derivatives with the highest cytotoxic activity were selected, and an apoptosis assay was carried out by flow cytometry, which supported that apoptosis is the major mechanism.
In this work, a facile, efficient and metal free catalytic system has been developed for the synthesis of tetrahydrobenzo[a]xanthene derivatives via a one-pot three-component condensation of various aldehydes, 2-naphthol, and dimedone.
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