Giant bullous emphysema, also known as "vanishing lung syndrome", is a rare manifestation of chronic obstructive pulmonary disease (COPD) that is associated with high mortality. Cigarette smoking and alpha-1 antitrypsin deficiency (A1AD) are two main causes that result in permanent enlargement of airspaces, inefficient gas exchange, fibrosis of the airways, and collapse of the alveoli. A typical presentation can be found in a long-term smoker with dyspnea on exertion and progressive shortness of breath that may be associated with a productive cough. One of the clinical difficulties in diagnosing giant bullous emphysema is separating it from other etiologies like pneumothorax. It is paramount to differentiate giant bullous emphysema from pneumothorax as the management is completely different; both can, however, have similar clinical presentations and radiographic manifestations on initial assessment. In this report, we present the case of a 39-year-old African American male who presented with worsening shortness of breath and productive cough and was found to have bullous emphysema but was misdiagnosed and treated for pneumothorax in the initial encounter. The purpose of this case report is to raise awareness of this condition in the medical literature and discuss the similarity of bullous emphysema and pneumothorax in clinical presentation and radiographic findings, as well as the differences in treatment options.
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