Potential drug interactions prevalence in intensive care units Prevalência de potenciais interações medicamentosas droga-droga em unidades de terapia intensiva ORIGINAL ARTICLE INTRODUCTION A drug interaction takes place when the effects and/or toxicity of a drug are affected by another drug. (1,2) Although results may be positive (increased efficacy) or negative (decrease of efficacy, toxicity or idiosyncrasy), in pharmacotherapy they are usually unforeseen and undesirable. (3) With the continued development of new drugs and subsequent prescriptions with increasingly more complex combinations it has become difficult for physicians and pharmaceutics to be familiar with all potential interactions. (4) Risk of occurrence and severity rest upon several factors, among them
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