Despite rapid advances in both the early detection and treatment of cancer, the
mortality from this disease remains high, which justifies the development of new
products that are more selective and effective and have fewer side effects.
Accordingly, a novel ester was synthesized that contains two pharmacophores with
important biological activities: (I) 4-aminoantipyrine, which has
anti-inflammatory and antioxidant effects, and (II) the pharmacophore
1,4-dioxo-butenyl, which has cytotoxic activity. When administered alone, this
compound is non-genotoxic, and it does not cause an increasing in splenic
phagocytosis. Nevertheless, it can induce cell death. When administered in
combination with commercial chemotherapeutic agents, such as doxorubicin,
cisplatin, and cyclophosphamide, the ester shows antigenotoxic activity and
decreases phagocytosis and reduces the potential to cause cell death. These
results indicate that the compound should not be used in combination with
chemotherapeutic agents that exert their effect through DNA damage, an important
feature of antitumor drugs.
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