Objective The objective of the present study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) included in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. Patients and Methods The ANRS CO3 Aquitaine cohort prospectively collects epidemiological, clinical, biological and therapeutic data on PLHIV in the French Aquitaine region. Two cross sectional analyses were performed in 2004 and 2014, regarding patient characteristics, HIVRNA and CD4 counts and prevalence of some of the common comorbidities and treatment. Results 2,138 PLHIV (71% male, median age 52.2 years in 2014), who had at least one visit registered in the cohort both in 2004 and 2014 were included in the study. We have observed a significant increase in the prevalence of diagnosed chronic kidney disease (CKD), bone fractures, cardiovascular events (CVE), hypertension, diabetes and dyslipidaemia as well as an increase in treatment or prevention for these conditions (statins, clopidogrel, aspirin). This is also reflected in an increase in the proportion of patients in the high or very high risk groups in the different disease risk scores for CKD, CVE and bone fracture score. Conclusions Between 2004 and 2014, the population aged and experienced an overall higher prevalence of non-HIV related comorbidities, including CKD and CVD. Careful HIV management according to current recommendations, and optimal selection of antiretrovirals, in addition to a good control of risk factors for these comorbidities, through lifestyle improvements and preventative measures, could lead to an early management of these comorbidities and to a continuous improvement of PLHIV health status.
Background: The objective of the present study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) included in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. Methods: The ANRS CO3 Aquitaine cohort prospectively collects epidemiological, clinical, biological and therapeutic data on PLHIV in the French Aquitaine region. Two cross sectional analyses were performed in 2004 and 2014, regarding patient characteristics, HIVRNA and CD4 counts and prevalence of some of the common comorbidities and treatment. Results: 2,138 PLHIV (71% male, median age 52.2 years in 2014), who had at least one visit registered in the cohort both in 2004 and 2014 were included in the study. We have observed a significant increase in the prevalence of diagnosed chronic kidney disease (CKD), bone fractures, cardiovascular events (CVE), hypertension, diabetes and dyslipidaemia as well as an increase in treatment or prevention for these conditions (statins, clopidogrel, aspirin). This is also reflected in an increase in the proportion of patients in the high or very high risk groups in the different disease risk scores for CKD, CVE and bone fracture score. Conclusions: Between 2004 and 2014, the population aged and experienced an overall higher prevalence of non-HIV related comorbidities, including CKD and CVD. Careful HIV management according to current recommendations, and optimal selection of antiretrovirals, in addition to a good control of risk factors for these comorbidities, through lifestyle improvements and preventative measures, could lead to an early management of these comorbidities and to a continuous improvement of PLHIV health status.
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