Background: The discovery of early, non-invasive biomarkers for the identification of “preclinical” or “pre-symptomatic” Alzheimer's disease and other dementias is a key issue in the field, especially for research purposes, the design of preventive clinical trials, and drafting population-based health care policies. Complex behaviors are natural candidates for this. In particular, recent studies have suggested that speech alterations might be one of the earliest signs of cognitive decline, frequently noticeable years before other cognitive deficits become apparent. Traditional neuropsychological language tests provide ambiguous results in this context. In contrast, the analysis of spoken language productions by Natural Language Processing (NLP) techniques can pinpoint language modifications in potential patients. This interdisciplinary study aimed at using NLP to identify early linguistic signs of cognitive decline in a population of elderly individuals.Methods: We enrolled 96 participants (age range 50–75): 48 healthy controls (CG) and 48 cognitively impaired participants: 16 participants with single domain amnestic Mild Cognitive Impairment (aMCI), 16 with multiple domain MCI (mdMCI) and 16 with early Dementia (eD). Each subject underwent a brief neuropsychological screening composed by MMSE, MoCA, GPCog, CDT, and verbal fluency (phonemic and semantic). The spontaneous speech during three tasks (describing a complex picture, a typical working day and recalling a last remembered dream) was then recorded, transcribed and annotated at various linguistic levels. A multidimensional parameter computation was performed by a quantitative analysis of spoken texts, computing rhythmic, acoustic, lexical, morpho-syntactic, and syntactic features.Results: Neuropsychological tests showed significant differences between controls and mdMCI, and between controls and eD participants; GPCog, MoCA, PF, and SF also discriminated between controls and aMCI. In the linguistic experiments, a number of features regarding lexical, acoustic and syntactic aspects were significant in differentiating between mdMCI, eD, and CG (non-parametric statistical analysis). Some features, mainly in the acoustic domain also discriminated between CG and aMCI.Conclusions: Linguistic features of spontaneous speech transcribed and analyzed by NLP techniques show significant differences between controls and pathological states (not only eD but also MCI) and seems to be a promising approach for the identification of preclinical stages of dementia. Long duration follow-up studies are needed to confirm this assumption.

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Abstract. A precise identification of prosodic phenomena and the construction of tools able to properly manage such phenomena are essential steps to disambiguate the meaning of certain utterances. In particular they are useful for a wide variety of tasks: automatic recognition of spontaneous speech, automatic enhancement of speechgeneration systems, solving ambiguities in natural language interpretation, the construction of large annotated language resources, such as prosodically tagged speech corpora, and teaching languages to foreign students using Computer Aided Language Learning (CALL) systems. This paper presents a study on the automatic detection of prosodic prominence in continuous speech, with particular reference to American English, but with good prospects of application to other languages. Prosodic prominence involves two different prosodic features: pitch accent and stress accent. Pitch accent is acoustically connected with fundamental frequency (F0) movements and overall syllable energy, whereas stress exhibits a strong correlation with syllable nuclei duration and mid-to-high-frequency emphasis. This paper shows that a careful measurement of these acoustic parameters, as well as the identification of their connection to prosodic parameters, makes it possible to build an automatic system capable of identifying prominent syllables in utterances with performance comparable with the inter-human agreement reported in the literature. Two different prominence detectors were studied and developed: the first uses a training corpus to set up thresholds properly, while the second uses a pure unsupervised method. In both cases, it is worth stressing that only acoustic parameters derived directly from speech waveforms are exploited.

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