Introduction: Glomerular diseases are a frequent etiology of chronic kidney disease, especially in the developing countries. Objective: To determine the profile of such glomerulopathies in a public hospital located in the city of Brasilia, Federal District. Methods: 121 renal biopsies in different patients were performed by the Renal Division of Hospital Regional da Asa Norte (HRAN) between August 2005 and May 2009. Eight renal biopsies in renal-transplant patients were excluded and the medical records of 113 remaining patients were analyzed. Analyzed data: sex, age, laboratory exams, glomerular syndrome, clinical diagnosis, degree of interstitial fibrosis, immunosuppressants use, need for dialysis and clinical outcome. Results: The age average was 34.9 ± 16.2 years-old, a predominance of male patients (51.3%). Major glomerular syndromes were: nephrotic syndrome (41.6%) and the rapidly-progressive glomerulonephritis (35.4%). Among primary glomerulopathies focal glomerulosclerosis (26.8%) followed by IgA nephropathy (25%) were predominant; and among the most prevalent secondary glomerulopathies we had lupus nephritis (50%) and diffuse exudative proliferative glomerulonephritis (34.2%).The majority of the patients used immunosuppressants (68.1%) and almost one third of them (29.2%) needed dialysis during their hospitalization. Progressed to chronic dialysis therapy 13.3% of the patients and 10.6% died. Conclusion: This study may contribute to better epidemiological understanding of glomerular diseases in the Federal District, guiding the adoption of public policies aiming the quick clinical treatment of such diseases. Keywords: nephropathy, nephritis, glomerulonephritis, nephrotic syndrome, lupus syndrome, focal segmental glomerulosclerosis, IgA nephropathy, chronic kidney disease [J Bras Nefrol 2010;32(3):248-255]©Elsevier Editora Ltda. Profile of glomerular diseases in a public hospital of Federal District, Brazil IntroductIonChronic kidney disease is currently understood as a public health problem, because of its increasing prevalence, high morbidity and mortality, and high costs for maintaining patients with chronic kidney disease (CKD) stage 5 in different modalities of renal replacement therapy (RRT) (hemodialysis, peritoneal dialysis, and kidney transplantation).1-3 Currently, over one million people worldwide are estimated to be on any form of chronic dialysis therapy, and Latin America accounts for almost one quarter of such patients. [4][5][6] The cost of that treatment is high: Brazilian data have shown that more than 10% of the budget of the Health Ministry is destined to maintain RRT programs, while North-American data point to a cost of 29 billion dollars per year to treat patients that need RRT. 7,8 In Brazil, as in several other countries, glomerular diseases are a frequent etiology of chronic kidney failure, 9,10 and kidney biopsy plays a fundamental role in the correct histopathological and etiological diagnosis and even in the prognosis of such cases. 11,12Glomerular diseases often have ...

End-stage renal disease (ESRD) is an important public health problem, especially in developing countries due to the high level of economic resources needed to maintain patients in the different programs that make up renal replacement therapy (RRT). To analyze the differences and inequalities involved in access to RRT in the BRICS countries (Brazil, Russian Federation, India, China and South Africa). This is an applied, descriptive, cross-sectional, quantitative and qualitative study, with documentary analysis and a literature review. The sources of data were from national censuses and scientific publications regarding access to RRT in the BRICS countries. There is unequal access to RRT in all the BRICS countries, as well as the absence of information regarding dialysis and transplants (India), the absence of effective legislation to inhibit the trafficking of organs (India and South Africa) and the use of deceased prisoners as donors for renal transplants (China). The construction of mechanisms to promote the sharing of benefits and solidarity in the field of international cooperation in the area of renal health involves the recognition of bioethical issues related to access to RRT in the BRICS countries.

The granulomatosis with polyangiitis, initially known as Wegener's granulomatosis, is a small and medium vessels vasculitis. It's classic form presents a triad: necrotizing granuloma of respiratory tract, necrotizing cutaneous vasculitis and glomerulonephritis. This vasculitis has cytoplasmic antineutrophil antibodies as signal. This work illustrates a case, of multisystemic rare disease, in which the segment and treatment were considered satisfactory for symptoms remission.

AGRADECIMENTOS À Deus, por unguentar minhas feridas e ensinar-me o caminho do perdão e da redenção pela Cruz de Cristo. A minha família, sobretudo a minha esposa, amiga e companheira Natasha Rebouças Ferraroni e minhas filhas Nicole e Alice, pelo amor, carinho e compreensão com minhas faltas e ausências. A meu pais Geraldo e Vera, meus irmãos Ingrid e Hector e meu tio João pelo apoio para que eu trilhasse essa jornada. A Maria Alves Pires, por ser a melhor "dinda"que minhas filhas poderiam ter. Ao meu orientador, Prof Dr Natan Monsores de Sá, pela atenção, paciência e dedicação comigo quando mais precisei. Ao Programa de Pós-graduação em Bioética da Universidade de Brasília, liderado com maestria pelo Professor Doutor Volnei Garrafa. Ao Dr Cláudio Lorenzo, pelo apoio dado a mim durante o curso de Especialização em Bioética. Aos meus colegas do curso de especialização da Cátedra UNESCO de Bioética, e também aos colegas da pós-graduação, pela amizade e companheirismo. Aos meus colegas preceptores e aos médicos residentes do Hospital Regional da Asa Norte (HRAN) pela paciência com minhas contingências, sobretudo aos colegas da nefrologia (Dr Sérgio Cavecchia,

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