of New Tetracyclic 3-(Trifluoromethyl)-spiro(chromen[4,3-c]pyrazole-4,1'-cycloalkanes). -Reaction of trifluoroacetylated Kabbe adducts (IV) with phenylhydrazine or methylhydrazine proceeds with apposite regioselectivity furnishing chromenopyrazoles (VI) or (VIII), respectively. -(BONACORSO*, H. G.; GARCIA, F. D.; BELO, C. R.; TIER, A. Z.; FRIZZO, C. P.; MARTINS, M. A. P.; ZANATTA, N.; J. Fluorine Chem. 166 (2014) 44-51, http://dx.
This article discloses the synthesis and biological in vitro activity of a novel class of compounds derived from 5′‐arylchalcogenyl‐3‐(phenylselanyl‐triazoyl)‐thymidine as antitumor agents in the 5637 bladder carcinoma. The synthesis of the new molecules obtained good yields and proved to be efficient. The antitumor biological property, which was presented by a series of these unpublished compounds, demonstrates the importance of the presence of the nucleoside portion and the chalcogenium atom in the molecule.
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