The inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, may be considered as one of the treatment approaches against several neurological disorders including Alzheimer’s. The purpose of this study is to evaluate, compare, and discuss the anti-acetylcholinesterase activity of three methanolics extracts from Hyptis leaves: Hyptis marrubioides (Hm), Hyptis pectinate (Hp), and Hyptis suaveolens (Hs). AChE activity was measured using a modified 96-well microplate assay based on Ellman’s method. IC50 (half maximal inhibitory concentration) values were calculated for Hm, Hp, and Hs methanolic extracts using physostigmine as a positive control. All the extracts exhibited a dose-dependent AChE percent inhibition with IC50 values lower for Hm, followed by Hp and Hs. Several polyphenols (such as flavonoids and phenolic acids) have been considered a prominent source of anti-Alzheimer disease compounds because of their potential AChE inhibitory activity allied to their well-known antioxidant activity and low toxicity. The results obtained are discussed under the light of the available literature regarding the phytochemical composition and antioxidant activity of Hyptis spp. extracts. Further studies are warranted regarding the role of these Hyptis extracts in the progression of neurological disorders.
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